{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:50:26Z","timestamp":1791759026229,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Drug shortages are a growing challenge in health systems across the world. A better understanding of the impacts of shortages on patient drug access and use will guide policies aimed at mitigating shortages. This scoping review aims to summarize observational literature assessing the impact of drug shortages on drug utilization trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Ovid MEDLINE and Ovid EMBASE for studies published between 1946 and September 17, 2024. An extensive grey literature search was conducted through targeted website searches, grey literature databases, and the Google search engine. Observational studies examining the impacts of drug shortages on drug use were included. Study screening and extraction were conducted by two independent reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 55 published articles and five gray literature reports. Most studies were conducted in North America (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942, 70%). Population\u2010level data were most used (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 57%), and most studies used drug prescription data to assess changes in use (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930, 55%). Most studies reported changes in drug use as a percent change, and the magnitude in decreases ranged from 1% to 99%. Many different data sources, methods, and measures were used to study the impact of drug shortages on drug utilization, and a broad range of decreases in drug utilization following the shortages were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is important to synthesize findings across studies to understand how different drugs and settings are affected by shortages. The findings here will inform future studies aimed at filling this knowledge gap, ultimately yielding real\u2010world evidence that can guide policy decisions to address drug supply challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70178","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:58:43Z","timestamp":1751432323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of Supply Chain Disruptions and Drug Shortages on Drug Utilization: A Scoping Review"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-8557","authenticated-orcid":false,"given":"Araniy","family":"Santhireswaran","sequence":"first","affiliation":[{"name":"Leslie dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanzeh","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Leslie dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ho","sequence":"additional","affiliation":[{"name":"Leslie dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Fuller","sequence":"additional","affiliation":[{"name":"Angus L. Macdonald Library St. Francis Xavier University  Antigonish Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Gaudette","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Burry","sequence":"additional","affiliation":[{"name":"Leslie dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"},{"name":"Mount Sinai Hospital Sinai Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Tadrous","sequence":"additional","affiliation":[{"name":"Leslie dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization \u201cShortages Impacting Access to Glucagon\u2010Like Peptide 1 Receptor Agonist Products; Increasing the Potential for Falsified Versions \u201d2024 https:\/\/www.who.int\/news\/item\/29\u201001\u20102024\u2010shortages\u2010impacting\u2010access\u2010to\u2010glucagon\u2010like\u2010peptide\u20101\u2010receptor\u2010agonist\u2010products\u2010\u2010increasing\u2010the\u2010potential\u2010for\u2010falsified\u2010versions."},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization \u201cMeeting Report: Technical Definitions of Shortages and Stockouts of Medicines and Vaccines \u201d2016."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.044494"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2841"},{"issue":"11","key":"e_1_2_8_6_1","first-page":"740","article-title":"The Drug Shortage Crisis in the United States: Causes, Impact, and Management Strategies","volume":"36","author":"Ventola C. L.","year":"2011","journal-title":"Pharmacy and Therapeutics"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110210"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.70035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1934"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010023\u201002178\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES\u201021\u201000483"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u20105908\u20105\u201069"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-12"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"A.Santhireswaran K.Fuller E.Gaudette L.Burry andM.Tadrous \u201cImpact of Supply Chain Issues and Drug Shortages on Drug Utilization: A Scoping Review \u201d2023 https:\/\/doi.org\/10.17605\/OSF.IO\/2P6E5.","DOI":"10.1371\/journal.pone.0313298"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313298"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.4246"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010023\u201007958\u20106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215837"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293497"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T03:18:46Z","timestamp":1754968726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/pds.70178"],"URL":"https:\/\/doi.org\/10.1002\/pds.70178","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70178"}}