{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T21:09:10Z","timestamp":1770844150522,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002329","name":"Bundesamt f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013120","name":"European Medicines Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe an international response to the COVID\u201019 pandemic by estimating the prevalence of medication use for COVID\u201019 treatment in pregnancy, stratified by hospitalization, trimester of pregnancy, and country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a two\u2010stage individual participant data meta\u2010analysis of proportions from primary data on medications used to treat COVID\u201019 during pregnancy. A common data model was developed to pool the data from single\u2010country and international registries. Data from pregnant individuals with COVID\u201019 between February 2020 and October 2022 were included in study platforms across 9 data sources. Patient information was abstracted from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 24\u2009937 pregnant individuals, the pooled prevalences of individuals receiving medications to treat COVID\u201019 were: 34.7% heparin, 9.8% antibiotics, 4.9% corticosteroids, 2.2% antivirals, 0.8% antimalarials, 0.3% convalescent plasma, 0.2% immunosuppressants, and 0.02% monoclonal antibodies. Prevalence of medication use was higher in hospitalized individuals than in non\u2010hospitalized individuals: 58.4% versus 17.9% for heparin, 26.9% versus 5.7% for antibiotics, 17.5% versus 1.3% for corticosteroids, 10.3% versus 0.3% for antivirals, and 4.5% versus 0.1% for antimalarials. The prevalence of corticosteroid use was lower in the first trimester (0.1%) compared with the second (7.2%) and third (4.9%) trimesters of pregnancy. The prevalence of medications differed widely across countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Medication to treat COVID\u201019 was more frequently used in pregnant individuals hospitalized for COVID\u201019. Corticosteroids were used less in the first trimester of pregnancy. The differences in use between countries could reflect differences in the clinical management and access to medications for this population at risk of severe disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.70180","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:54:17Z","timestamp":1752724457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How <scp>COVID<\/scp>\u201019 Treatment in Pregnancy Reflects Healthcare Utilization During a Pandemic: A Two\u2010Stage Individual Participant Data Meta\u2010Analysis Combining Case\u2010Based Registries"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-4468","authenticated-orcid":false,"given":"Emeline","family":"Maisonneuve","sequence":"first","affiliation":[{"name":"Materno\u2010Fetal and Obstetrics Research Unit, Department \u201cFemme\u2010M\u00e8re\u2010Enfant\u201d University Hospital 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