{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:17:59Z","timestamp":1784647079687,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Linking claims data to electronic health record (EHR) data can improve completeness, often at a cost of decreased sample size. Quantifying information gained and differences in patient characteristics between EHR and EHR\u2010claims linked cohorts may inform study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using ConcertAI Patient360 EHR linked to multiple closed insurance claims sources, we compared an EHR cohort of patients with incident metastatic breast cancer (mBC) to an EHR\u2010claims subcohort (requiring \u2265\u200990\u2009days claims coverage). We analyzed diagnosis coverage, patient time during lookback and follow\u2010up, baseline characteristics, and rates of 14 adverse events (AEs). Analyses were age stratified due to insurance coverage changes at age 65.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For the EHR cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096289), 1438 (23%) were in the EHR\u2010claims subcohort. A greater proportion were aged \u2265\u200965\u2009years in the EHR cohort (30%) than in the EHR\u2010claims subcohort (17%). EHR\u2010claims patients had longer observation periods and more unique diagnoses across both age groups. For most AEs, incidences were higher in both age groups in the EHR\u2010claims subcohort than in the EHR cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EHR\u2010claims provided more diagnoses and observation time, at the cost of a reduction in sample size and underrepresentation of patients \u2265\u200965\u2009years. Differing age proportions support age\u2010stratified or standardized analyses for EHR\u2010claims data. Results aid interpretation of differences between EHR and EHR\u2010claims results due to shifts in age, completeness of diagnosis history, and duration of observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70213","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T03:26:03Z","timestamp":1758684363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of Information Gained by Linking Claims Data to an Electronic Health Record Cohort of Patients With Metastatic Breast Cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Jonah","family":"Geddes","sequence":"first","affiliation":[{"name":"SimulStat Incorporated  Solona Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Katz","sequence":"additional","affiliation":[{"name":"Gilead Sciences  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Asiimwe","sequence":"additional","affiliation":[{"name":"Gilead Sciences  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Brookhart","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Carroll","sequence":"additional","affiliation":[{"name":"Gilead Sciences  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Eldemir","sequence":"additional","affiliation":[{"name":"Datavant  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Mucaj","sequence":"additional","affiliation":[{"name":"Datavant  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Nolan","sequence":"additional","affiliation":[{"name":"Gilead Sciences  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Ntalla","sequence":"additional","affiliation":[{"name":"Gilead Sciences Europe Ltd.  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-7839","authenticated-orcid":false,"given":"Carrie M.","family":"Nielson","sequence":"additional","affiliation":[{"name":"Gilead Sciences  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(22)00154-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.359"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2053951717745678"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2013.06.010"},{"key":"e_1_2_13_6_1","unstructured":"L. D. B.Slipski Y.Yu M.Walker andY.Natanzon \u201cAddition of Open Administrative Claims Significantly Improves Capture of Mortality in Electronic Health Record \u201dPresented at: ISPOR; November 17\u201020 2024; Barcelona Spain https:\/\/www.ispor.org\/conferences\u2010education\/conferences\/past\u2010conferences\/ispor\u2010europe\u20102024\/program\/program\/session\/euro2024\u20104013\/142887."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooac040"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-024-02416-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020.08.106"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.450"},{"key":"e_1_2_13_11_1","unstructured":"M. R.Stedman P.Doria\u2010Rose J. L.Warren C. N.Klabunde andA.Mariotto \u201cComorbidity Technical Report: The Impact of Different SEER\u2010Medicare Claims\u2010Based Comorbidity Indexes on Predicting Non\u2010Cancer Mortality for Cancer Patients \u201dhttps:\/\/Healthcaredelivery.Cancer.Gov\/Seermedicare\/Considerations\/Comorbidity\u2010Report.Pdf."},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06469-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2728-9"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252925"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2022.07.007"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3027"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13822"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2023.2288147"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2023.2267975"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"issue":"3","key":"e_1_2_13_21_1","article-title":"Strategies for Handling Missing Data in Electronic Health Record Derived Data","volume":"1","author":"Wells B. 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