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Most organizations still rely largely on analyses of individual case reports and pre\u2010existing evidence \u2013 especially during signal detection and validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This paper presents a set of recommendations for efforts to enable broader use of real\u2010world evidence throughout pharmacovigilance signal management, in the future.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>The recommendations regard streamlined data access, data harmonization and use of reproducible analytical workflows to enable rapid and robust evidence generation. They emphasize the need for cross\u2010disciplinary collaboration and for organizational adaptations to ensure adequate competence and supporting processes, including principles for how to integrate new types of evidence in decision\u2010making. The execution of pilot studies under realistic conditions and the dissemination of their findings are highlighted as important steps toward defining the proposed change and driving progress in this area. This manuscript is endorsed by the International Society for Pharmacoepidemiology (ISPE).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70231","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:01:04Z","timestamp":1759993264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recommendations to Enable Broader Use of Real\u2010World Evidence to Inform Decision\u2010Making Throughout Pharmacovigilance Signal Management"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-230X","authenticated-orcid":false,"given":"G. 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