{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T07:31:02Z","timestamp":1767079862452,"version":"3.48.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020320","name":"Institut pour la Recherche en Sant\u00e9 Publique","doi-asserted-by":"publisher","award":["INCa\/IReSP 16648"],"award-info":[{"award-number":["INCa\/IReSP 16648"]}],"id":[{"id":"10.13039\/501100020320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA289226"],"award-info":[{"award-number":["U01CA289226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The ongoing global increase in opioid use necessitates studies examining long\u2010term health impacts. Prospective cohorts frequently rely on self\u2010reported medication use data which may be subject to several types of bias compared to more objective measurements. We evaluated the agreement between two opioid exposure measures in the UK Biobank (UKBB)\u2014self\u2010reported regular use and prescription\u2010based indicators using linked general practitioner (GP) records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our analysis included 171\u2009813 UKBB participants with linked prescription records. At baseline, participants reported medications taken regularly (weekly, monthly, every 3\u2009months). We assessed agreement between self\u2010reported regular opioid use and opioid prescription records prior to enrollment across various look\u2010back periods and prescription counts. Logistic regressions assessed factors associated with omission and commission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Agreement was moderate to substantial between self\u2010reported opioid use and prescription records. The strongest agreement was observed for \u2265\u20093 prescriptions in the past 365\u2009days (Cohen's Kappa\u2009=\u20090.66). Subgroup analysis showed better agreement for analgesic opioids (Kappa\u2009=\u20090.43\u20130.63) than for non\u2010analgesic opioids (Kappa\u2009=\u20090.25\u20130.34). Omission odds were highest with increasing months since the last record and lowest for individuals with chronic pain. Commission odds were highest for individuals with chronic pain and lowest in married\/partnered individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis indicates that self\u2010reported regular opioid use in the UKBB could be a valid indicator for identifying individuals with repeated prescriptions for analgesic opioids in the past year, while also capturing opioid use from non\u2010linked sources. However, agreement was low for non\u2010analgesic opioids, suggesting limited utility of self\u2010report for capturing use of these medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70280","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:05:34Z","timestamp":1765188334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Measuring Exposure to Opioids Using Self\u2010Reported Medication Use Data Versus General Practitioner Prescription Records in the\n                    <scp>UK<\/scp>\n                    Biobank Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Allison","family":"Domingues","sequence":"first","affiliation":[{"name":"Genomic Epidemiology Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhai","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Odile","family":"Parat","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Viallon","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Degenhardt","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallie\u2010Anne","family":"Pearson","sequence":"additional","affiliation":[{"name":"School of Population Health University of New South Wales Sydney  Sydney New South Wales Australia"},{"name":"Medicines Intelligence Research Program University of New South Wales Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Genomic Epidemiology Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"},{"name":"School of International Business China Pharmaceutical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-7824","authenticated-orcid":false,"given":"Mahdi","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Genomic Epidemiology Branch International Agency for Research on Cancer (IARC\u2010WHO)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECLINM.2021.101198"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/20494637231160684"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECLINM.2023.102079"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(18)30232\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1923"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BJA.2022.12.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16142564"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/OXFORDJOURNALS.AJE.A117563"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(99)00167\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.10.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCLINEPI.2007.10.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047\u20102797(98)00072\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"R. 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