{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:15:51Z","timestamp":1781104551812,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study developed and validated algorithms to identify the incidence of endometrial cancer using ICD\u20109\u2010CM and ICD\u201010\u2010CM coding systems as part of a post\u2010authorization safety study (EU PAS: EUPAS45602) of vaginal estrogen, estrogen and progestin combination hormone therapy, and non\u2010users of vaginal estrogen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using national claims data in the HealthCare Integrated Research Database, provisional endometrial cancer cases were identified using a screening algorithm comprising at least one endometrial cancer diagnosis code at any location and position between January 1, 2007 and December 31, 2021. One medical record per case was obtained for 700 provisional cases. Two experts in obstetrics and gynecology adjudicated the medical records classifying each patient as a confirmed case, confirmed non\u2010case, or unknown. Positive predictive value (PPV), conditional sensitivity assuming all cases were identified by the screening algorithm, and their respective 95% confidence intervals (CI) were calculated. Algorithms were generated by choosing the codes and number of encounters to balance endometrial cancer detection and false positives. Algorithms were trained in a sample of non\u2010users of vaginal estrogen and tested across treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the non\u2010user training set, two visits with ICD\u20109\u2010CM code 182.0 or 182.8 had a PPV of 91.2% (85.4%\u201395.2%) and sensitivity of 99.3% (95.9%\u2013100.0%). Two visits on separate days with ICD\u201010\u2010CM code C54.1, C54.8, or C54.9 had a PPV of 97.0% (93.6%\u201398.9%) and sensitivity of 99.5% (97.2%\u2013100.0%). PPVs and sensitivities were over 75% across testing set cohorts for both algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Two visits with an endometrial cancer diagnosis code accurately identified endometrial cancer cases in both coding systems. There were very few false positive endometrial cancer diagnoses. PPVs and sensitivities were high and similar in all cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70306","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:25:16Z","timestamp":1769048716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and Validation of an Endometrial Cancer Algorithm in\n                    <scp>US<\/scp>\n                    Claims Data"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1862-5634","authenticated-orcid":false,"given":"Kimberly","family":"Daniels","sequence":"first","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cachet","family":"Wenziger","sequence":"additional","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampada","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schott","sequence":"additional","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Coley","sequence":"additional","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Goldstein","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-4566","authenticated-orcid":false,"given":"Lauren","family":"Parlett","sequence":"additional","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Shanmugasandaram","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wolter","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Dai","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Azarmina","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lanes","sequence":"additional","affiliation":[{"name":"Carelon Research  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"National Cancer Institute Cancer Stat Facts: Uterine Cancer. Cancer Statistics Web Site. Accessed December 12 2024(2024) https:\/\/seer.cancer.gov\/statfacts\/html\/corp.html."},{"key":"e_1_2_11_3_1","unstructured":"Centers for Disease Control and Prevention Uterine Cancer Risk Factors. Accessed June 6 2024(2024) https:\/\/www.cdc.gov\/uterine\u2010cancer\/risk\u2010factors\/index.html."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.7.527"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.485"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.2820"},{"key":"e_1_2_11_7_1","unstructured":"The Mayo Clinic Endometrial Cancer. Diseases & Conditions Web Site. Accessed 2025(2025) https:\/\/www.mayoclinic.org\/diseases\u2010conditions\/endometrial\u2010cancer\/diagnosis\u2010treatment\/drc\u201020352466."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1938952"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.70110"},{"key":"e_1_2_11_10_1","volume-title":"StatPearls Treasure Island (FL) Ineligible Companies","author":"Peacock K.","year":"2025"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5690"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa090"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5109"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116805"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:11:41Z","timestamp":1773191501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/pds.70306"],"URL":"https:\/\/doi.org\/10.1002\/pds.70306","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70306"}}