{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:43:43Z","timestamp":1773254623607,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010113\u2010022"],"award-info":[{"award-number":["DMR\u2010113\u2010022"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010114\u2010064"],"award-info":[{"award-number":["DMR\u2010114\u2010064"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW110\u2010TDU\u2010B\u2010212\u2010124004"],"award-info":[{"award-number":["MOHW110\u2010TDU\u2010B\u2010212\u2010124004"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 109\u20102314\u2010B\u2010039\u2010044"],"award-info":[{"award-number":["MOST 109\u20102314\u2010B\u2010039\u2010044"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigates the impact of Balance solutions on the risks of technique failure, death, and the first episode of peritonitis in incident peritoneal dialysis (PD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the database of Taiwan's National Health Insurance, patients with newly diagnosed end\u2010stage kidney disease receiving PD for at least 90\u2009days and treated with Balance solutions at the initiation of PD from 2009 to 2020 were identified. For each Balance solution user, 10 patients using conventional PD solutions, matched by the index year, were randomly selected as the control cohort. Risks of technique failure, death and the first episode of peritonitis were compared between the two cohorts by the end of 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the controls, the Balance solution users had an insignificant lower technique failure [156.3 vs. 172.0 per 1000 person\u2010years; adjusted hazard ratio (HR)\u2009=\u20090.92, 95% confidence interval (CI)\u2009=\u20090.79\u20131.08] and mortality (203.5 vs. 223.7 per 1000 person\u2010years; adjusted HR\u2009=\u20090.96, 95% CI\u2009=\u20090.83\u20131.09). The incident first episode of peritonitis was insignificant higher for the Balance solution cohort (139.9 vs. 117.1 per 1000 person\u2010years), with an adjusted HR\u2009=\u20091.14 (95% CI\u2009=\u20090.94\u20131.37). However, the adjusted HR of the first peritonitis episode was 1.24 (95% CI\u2009=\u20091.02\u20131.49) using the time\u2010dependent model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of Balance solution is associated with similar risks of technique failure and mortality, but probably an increased risk of the first episode of peritonitis, compared with the use of conventional solutions among incident PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70325","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:29:09Z","timestamp":1768724949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Balance Solution on the Outcomes of Incident Peritoneal Dialysis 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuu\u2010Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, College of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital, China Medical University  Taichung Taiwan"},{"name":"Division of Medical Genetics China Medical University Children's Hospital  Taichung Taiwan"},{"name":"Department of Medical Laboratory Science &amp; Biotechnology Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Anesthesiology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Chin","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Medicine China Medical University  Taichung Taiwan"},{"name":"Division of Nephrology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-8552","authenticated-orcid":false,"given":"Fung\u2010Chang","family":"Sung","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Health Services Administration China Medical University College of Public Health  Taichung Taiwan"},{"name":"Department of Food Nutrition and Health Biotechnology Asia University  Taichung 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