{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:15:15Z","timestamp":1789092915348,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trimethoprim\u2013sulfamethoxazole (TMP\u2013SMX) is associated with hypersensitivity and other adverse reactions. East Asian\u2013specific genetic susceptibility may increase severe adverse events, limiting the therapeutic use of TMP\u2013SMX for uncomplicated cystitis in Japan. However, data on its short\u2010term safety in this population are scarce. This study compared the short\u2010term safety of TMP\u2013SMX with fluoroquinolones for the treatment of uncomplicated cystitis using a nationwide Japanese claims database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the JMDC Claims Database (2006\u20132022). We included female outpatients aged \u2265\u200918\u2009years with acute uncomplicated cystitis who were newly treated with TMP\u2013SMX or fluoroquinolones (levofloxacin, ciprofloxacin, or tosufloxacin). The primary outcome was drug\u2010induced hypersensitivity (anaphylaxis or treatment\u2010requiring rash) within 7\u2009days after the prescription of these drugs. The secondary outcomes included treatment failure, all\u2010cause hospitalization, and other adverse events. Propensity score\u2010overlap weighting was applied to adjust for confounding. Subgroup analyses were stratified by age (&lt;\u200950 or \u2265\u200950\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 50\u2009773 eligible patients (TMP\u2013SMX, 2.1%; fluoroquinolones, 97.9%), the baseline characteristics were well balanced after weighting. The incidence of hypersensitivity did not differ significantly between the groups (0.9% vs. 0.7%; risk difference, 0.3%; 95% confidence interval, \u22120.3% to 0.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.410). No significant differences were observed for secondary outcomes. Subgroup analyses showed consistent results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Short\u2010term use of TMP\u2013SMX was not associated with increased risks of adverse events or treatment failure compared with fluoroquinolones. TMP\u2013SMX may represent a reasonable first\u2010line option for acute uncomplicated cystitis in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70342","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:15:49Z","timestamp":1772986549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of Short\u2010Term Trimethoprim\u2013Sulfamethoxazole Use for Uncomplicated Cystitis: A Nationwide Retrospective Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-9018","authenticated-orcid":false,"given":"Jumpei","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Aso","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1104429"},{"issue":"2","key":"e_1_2_14_3_1","first-page":"167","article-title":"Acute Uncomplicated UTIs in Adults: Rapid Evidence Review","volume":"109","author":"Kurotschka P. 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