{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:44:34Z","timestamp":1776397474671,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Accurate identification of non\u2010melanoma skin cancer (NMSC) using ICD\u201010 claims\u2010based algorithms is largely uncharacterized. This study aimed to develop and validate claim\u2010based algorithms for NMSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with psoriasis were identified in Optum Market Clarity between Oct 2015 and Dec 2020. Eligible patients had at least 1\u2009year of claim enrollment prior to cohort entry, linked claims\u2010EHRs, overlapping follow\u2010up periods, and no prior malignancy. Data were randomly split into the development and validation datasets. Broad NMSC encompassed narrow NMSC (basal cell carcinoma, squamous cell carcinoma, sebaceous cell carcinoma, and malignant neoplasms of the sweat glands), Merkel cell carcinoma, carcinoma in\u00a0situ, Kaposi sarcoma of skin, and cutaneous T\u2010cell or B\u2010cell lymphoma. The five developed claims\u2010based algorithms consisted of 1+ diagnosis code (1) at any position; (2) at the primary position; (3) by a dermatologist; (4) at any position plus treatment procedure code; (5) at primary position plus treatment procedure code. NMSC cases and non\u2010cases were adjudicated using EHR records. Algorithms performance measures were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 25\u2009647 patients (mean age 51.4\u2009\u00b1\u200915.2\u2009years, female 53.6%), 321 broad and 281 narrow NMSC patients were identified in the development dataset (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912\u2009824). Algorithm sensitivity was 89.9% (algorithm\u00a01) and 81.9% (algorithm\u00a02) but under 65% for algorithms 3\u20135 for broad NMSC. PPV ranged from 98.2% to 99.1%. Results were consistent in the validation dataset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study developed and validated high\u2010performing ICD10\u2010based algorithms for NMSC to facilitate future dermatology research using health data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70345","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:37:07Z","timestamp":1773293827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of Claims\u2010Based Algorithms for Non\u2010Melanoma Skin Cancer in Patients With Psoriasis Using Optum Market Clarity"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-4784","authenticated-orcid":false,"given":"Huifang","family":"Liang","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology Center of Excellence, Global Epidemiology, Pharmacovigilance &amp; Patient Safety, Epidemiology, and R&amp;D Quality Assurance AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-9180","authenticated-orcid":false,"given":"Shu","family":"Huang","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Center of Excellence, Global Epidemiology, Pharmacovigilance &amp; Patient Safety, Epidemiology, and R&amp;D Quality Assurance AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7918-0521","authenticated-orcid":false,"given":"Qiujie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Moorestown Dermatology Associates  Moorestown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-7183","authenticated-orcid":false,"given":"Dongmu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Center of Excellence, Global Epidemiology, Pharmacovigilance &amp; Patient Safety, Epidemiology, and R&amp;D Quality Assurance AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-0345","authenticated-orcid":false,"given":"Dianlin","family":"Guo","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Center of Excellence, Global Epidemiology, Pharmacovigilance &amp; Patient Safety, Epidemiology, and R&amp;D Quality Assurance AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-1379","authenticated-orcid":false,"given":"Simone P.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Center of Excellence, Global Epidemiology, Pharmacovigilance &amp; Patient Safety, Epidemiology, and R&amp;D Quality Assurance AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.109"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.02.015"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.1187"},{"key":"e_1_2_12_5_1","unstructured":"\u201cIncidence Rate of Malignancies Excluding Non\u2010Melanoma Skin Cancer in People aGed 20 and Older in the U.S. Surveillance Research Program \u201dNational Cancer Institute SEER*Stat Software Version 8.3.4. Based on Surveillance Epidemiology and End Results (SEER) Program SEER*Stat Database: Incidence\u2013SEER 18 Regs Research Data\u2009+\u2009Hurricane Katrina Impacted Louisiana Cases Nov 2016 Sub (2000\u20132014) <Katrina\/Rita Population Adjustment> \u2010Linked to County Attributes \u2010Toatl U.S. 1969\u20132015 Countries National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch Released April 2017 Based on the November 2016 Submission."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp352"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq132"},{"key":"e_1_2_12_8_1","unstructured":"Food and Drug Administration (FDA) Sentinel Initiative \u201cHydrochlorothiazide and Non\u2010Melanoma Skin Cancer \u201dhttps:\/\/www.sentinelinitiative.org\/studies\/drugs\/hydrochlorothiazide\u20100."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13619"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11101109"},{"key":"e_1_2_12_11_1","unstructured":"Food and Drug Administration Sentinel Health Initiative \u201cHealth Outcomes of Interest: Health Outcome Algorithm Inventory \u201dhttps:\/\/www.sentinelinitiative.org\/methods\u2010data\u2010tools\/health\u2010outcomes\u2010interest\/health\u2010outcome\u2010algorithm\u2010inventory."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.23.00165"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1357-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2023.102367"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-9276-5-12"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9150-9"},{"key":"e_1_2_12_17_1","unstructured":"Types of Skin Cancer \u201cCancer Research UK \u201dhttps:\/\/www.cancerresearchuk.org\/about\u2010cancer\/skin\u2010cancer\/types."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.37595"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2318"},{"key":"e_1_2_12_20_1","unstructured":"Food and Drug Administration (FDA) Sentinel \u201cHealth Outcomes of Interest. Alternative Methods for Health Outcomes of Interest Validation \u201d."},{"issue":"1","key":"e_1_2_12_21_1","first-page":"110","article-title":"Risk of Malignant Melanoma and Non\u2010Melanoma Skin Cancer in Rheumatoid Arthritis Patients Initiating Methotrexate Versus Hydroxychloroquine: A Cohort Study","volume":"41","author":"Lee H.","year":"2023","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2023.29.9.1033"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:51:37Z","timestamp":1776394297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/pds.70345"],"URL":"https:\/\/doi.org\/10.1002\/pds.70345","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70345"}}