{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:15Z","timestamp":1789657515172,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Safety data for most medications in pregnancy remain limited, yet pharmacological treatment is often necessary. Evidence on real\u2010world medication use in pregnancy including over\u2010the\u2010counter products and folic acid is scarce, especially in Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a drug utilization study using self\u2010reported data from BELpREG, a prospective, web\u2010based pregnancy registry established in November 2022. Pregnant individuals aged \u2265\u200918\u2009years receiving healthcare in Belgium can enrol voluntarily at any stage in pregnancy and complete online questionnaires at enrolment and every four weeks until delivery. All participants with follow\u2010up beyond the first trimester were included, and trimester\u2010specific cohorts were constructed based on completion of questionnaires after each trimester. Data were extracted in July 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 2096 participants, of whom 1767 were followed through trimester 2 and 1136 through trimester 3. Median gestational age at enrolment was 16\u2009weeks. Prevalence estimates of medication use were 80.2% in the six months before conception, 85.8% in trimester 1, 92.0% in trimester 2, and 94.9% in trimester 3. The most common classes were analgesics, vaccines, antihistamines, antianemic preparations, and drugs for acid\u2010related disorders. Paracetamol was most frequently used (35.4% in trimester 1), typically short term (median 3\u2009days), followed by doxylamine\u2010pyridoxine (26.7% in trimester 1). Folic acid supplementation was nearly universal, though only 59.9% met national guideline\u2010concordant criteria. Maternal vaccine uptake was substantial but incomplete, with 66.5% receiving pertussis, 43.7% influenza, and 24.4% COVID\u201019 vaccination. Exposure to potentially inappropriate or teratogenic medications was rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Medication use during pregnancy in Belgium was nearly universal, with high use of paracetamol and doxylamine\u2010pyridoxine. Folic acid and vaccine uptake were substantial, but often not guideline\u2010concordant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70369","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:13:54Z","timestamp":1775826834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medication, Vaccine, and Folic Acid Use Among Pregnant Women in Belgium: Insights from the\n                    <scp>BELpREG<\/scp>\n                    Cohort"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7545-2357","authenticated-orcid":false,"given":"Laure","family":"Sillis","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium"},{"name":"Research Foundation Flanders (FWO)  Brussel Belgium"},{"name":"L\u2010C&amp;Y\u2014KU Leuven Child &amp; Youth Institute  Leuven 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