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However, inappropriate self\u2010medication may pose health risks, particularly for individuals with chronic conditions. The aim of this study was to identify demographic, clinical, and psychosocial factors associated with self\u2010medication behavior after COVID\u201019 vaccinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Monocentric prospective cohort study at a vaccination center in Germany between August 16 and 28, 2021 with adults receiving a second dose of mRNA\u2010based COVID\u201019 vaccines. We used linear regression analyses to examine the association of self\u2010reported factors with the amount of self\u2010medication after vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1616 participants (median age 34\u2009years, 52% females) were included, with 536 (33.2%) reporting the use of self\u2010medication. Used substances were nonsteroidal anti\u2010inflammatory drugs\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009345 (21.3%), paracetamol\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009186 (11.5%), acetylsalicylic acid\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948 (3.0%), and metamizole\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918 (1.1%). The highest intake of any analgesic\/antipyretic was observed on the first day after vaccination\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009393 (24.3%). Factors associated with increased self\u2010medication included premedication with analgesics\/antipyretics (\n                      <jats:italic>B<\/jats:italic>\n                      : 0.545; 95% CI: 0.442; 0.651), administration of the mRNA\u20101273\u2010vaccine compared to the BNT162b2\u2010vaccine (\n                      <jats:italic>B<\/jats:italic>\n                      : 0.293; 95% CI: 0.188; 0.397), female gender (\n                      <jats:italic>B<\/jats:italic>\n                      : 0.159; 95% CI: 0.07; 0.249), prior experiences of vaccine reactions (\n                      <jats:italic>B<\/jats:italic>\n                      :0.117; 95% CI: 0.054; 0.18), expectations of vaccine reactions (\n                      <jats:italic>B<\/jats:italic>\n                      : 0.063; 95% CI: 0.003; 0.123), and the presence of common chronic conditions. A higher satisfaction with the vaccination process (\n                      <jats:italic>B<\/jats:italic>\n                      : \u22120.129; 95% CI: \u22120.222; \u22120.039) was associated with lower rates of self\u2010medication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Factors influencing self\u2010medication behavior after vaccination exist and could be assessed prior to vaccine administration. The observed association of previous experiences as well as expectations of vaccine reactions suggests that nocebo effects contribute to self\u2010medication practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70372","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:17:56Z","timestamp":1775819876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Self\u2010Medication to Mitigate Vaccine Reactions After\n                    <scp>COVID<\/scp>\n                    \u201019 Vaccination: A Prospective Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Maximilian","family":"Blattner","sequence":"first","affiliation":[{"name":"Department of General Practice and Primary Care University Medical Center Hamburg\u2010Eppendorf  Hamburg 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