{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:02:38Z","timestamp":1784512958955,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Prevalence of breast cancer (BC) increases with age, but the external validity of data obtained from pivotal trials of medicinal products remains a concern due to the underrepresentation of frail and older adults. Cyclin\u2010dependent kinase inhibitors (CDKi), palbociclib, abemaciclib, and ribociclib are considered an essential part of the standard\u2010of\u2010care in the management of advanced\/metastatic breast cancer. We investigated age, comorbidities, and survival in a nationwide real\u2010world cohort of CDKi users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the Finnish Cancer Registry, reimbursed dispensed prescriptions, Electronic Prescription Database, Care Register for Health Care (CRHC), and Causes of Death Register were combined and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether 1921 women with BC initiated CDKi treatment in 2018\u20132022. The median age at initiation was 66.9\u2009years, with 43.2% of the study cohort being &lt;\u200965\u2009years of age, 36.1% 65\u201374\u2009years, 19.0% 75\u201384\u2009years, and 1.7% 85\u2009years or older. The prevalence of age or frailty\u2010related comorbidities in individuals \u2265\u200965\u2009years was low, highest for cardiovascular diseases, 32.3%, and diabetes, 16.9%. The median survival was 25.3\u2009months, with longer median survival times in younger age groups (27.7\u2009months in &lt;\u200965\u2009year\u2010olds, 25.1\u2009months in aged 65\u201374, 21.4\u2009months in aged 75\u201384\u2009years, and 15.4\u2009months in 85\u2009years or older).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world CDKi users are older than women included in the pivotal trials, and the survival differences between age groups imply challenges in the generalisability of data from pivotal trials. The real\u2010world CDKi user population is characterised by a low prevalence of major comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70416","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:40:40Z","timestamp":1781617240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age, Age\u2010Related Comorbidities and Survival in Palbociclib, Ribociclib and Abemaciclib Users With Advanced Breast Cancer: A Nation\u2010Wide Retrospective Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Blair","family":"Rajamaki","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio 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