{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:59:28Z","timestamp":1781585968134,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["301977"],"award-info":[{"award-number":["301977"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["262700"],"award-info":[{"award-number":["262700"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To estimate the average gestational age for algorithm\u2010identified spontaneous abortions in Norway using interrupted time series analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used an algorithm to identify pregnancies registered in Norway from 2010 to 2020 and restricted to spontaneous abortions identified from primary and specialist care registers, and births from the Medical Birth Registry of Norway. For births, we calculated the first day of the last menstrual period (LMP; start of pregnancy) by subtracting the recorded gestational age from the birth date. We assigned spontaneous abortions an LMP corresponding to gestational ages ranging from 7 to 11\u2009weeks. We identified prescriptions from 70\u2009days before to 97\u2009days after LMP and calculated the number of antidepressant prescriptions per 10\u2009000 pregnancies per day. We applied two\u2010sample interrupted time series analysis to compare spontaneous abortions versus births. We compared antidepressant prescription trends between intervention points at 28 and 55 gestational days, the time when most pregnancies are recognized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our interrupted time series analysis including 122\u2009495 spontaneous abortions and 631\u2009929 births, the 7\u2010week assumption showed no post\u2010intervention trend, suggesting underestimation. The 9\u2010week assumption closely matched the trend for births (\u22120.051 prescriptions\/day, 95% CI \u22120.090 to \u22120.013 vs. \u22120.056, 95% CI: \u22120.067 to \u22120.046). The 8, 10, and 11\u2010week assumptions showed less precise alignment. The best alignment occurred with the 64\u2010day assumption (9.1\u2009weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study provides an empirically derived 64\u2010day average gestational age for algorithm\u2010identified spontaneous abortions in Norway, supporting future research, and this approach could help inform assumptions in other contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70417","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:42:32Z","timestamp":1781484152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimating the Gestational Age of Spontaneous Abortions Identified via Database Algorithms: An Empirical Analysis Using Interrupted Time Series"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-2108","authenticated-orcid":false,"given":"Chaitra","family":"Srinivas","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases Norwegian Institute of Public Health  Oslo Norway"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health  Oslo Norway"},{"name":"Department of Community Medicine and Global Health University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-0488","authenticated-orcid":false,"given":"Jacqueline M.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Norwegian Institute of Public Health  Oslo Norway"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198807283190401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1308"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1862"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23573"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475\u20106773.2006.00635.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4794"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0488"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.70002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010021\u201001113\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3284"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae372"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067407"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200011303432204"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1462"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3407"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4789"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4974"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006435.x"},{"issue":"26","key":"e_1_2_10_20_1","first-page":"2546","article-title":"Medisinsk f\u00f8dselsregister\u2014et sentralt utgangspunkt for perinatalmedisinsk forskning","volume":"122","author":"Irgens L. M.","year":"2002","journal-title":"Journal of the Norwegian Medical Association"},{"key":"e_1_2_10_21_1","unstructured":"Helsenorge \u201cPrenatal Ultrasound [in Norwegian] \u201d(2026) https:\/\/www.helsenorge.no\/undersokelse\u2010og\u2010behandling\/ultralyd\u2010av\u2010gravide\/."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l869"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003603"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2020.259"},{"issue":"2","key":"e_1_2_10_25_1","first-page":"S48","article-title":"The Norwegian Prescription Database (NorPD): New Register for Pharmacoepidemiological Research Covering a Whole Nation","volume":"14","author":"Furu K.","year":"2005","journal-title":"Pharmacoepidemiology and Drug Safety"},{"key":"e_1_2_10_26_1","volume-title":"Stata Statistical Software: Release 17","author":"StataCorp, L","year":"2021"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113220"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws393"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.16532"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.97360"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:51:09Z","timestamp":1781585469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/pds.70417"],"URL":"https:\/\/doi.org\/10.1002\/pds.70417","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70417"}}