{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:45:09Z","timestamp":1788583509792,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To determine the trajectories of benzodiazepine (BZD) and Z\u2010drug use among older adults (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093590) followed in a network of geriatric outpatient clinics in Brazil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This longitudinal study evaluated BZD and Z\u2010drug use over a 24\u2010month follow\u2010up period. The proportion of use at baseline and at the end of the study period was compared using the McNemar test. Two trajectories were considered:\n                      <jats:italic>started using<\/jats:italic>\n                      and\n                      <jats:italic>stopped using<\/jats:italic>\n                      . Comparisons between trajectories and independent variables were performed using Pearson's chi\u2010square test. Variables with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.20 were eligible for multivariate analysis. Multivariate models were also used to identify factors associated with BZD or Z\u2010drug use at baseline and with trajectories of initiation and discontinuation. Odds ratios (OR) with 95% confidence intervals were estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A small but significant reduction in overall BZD or Z\u2010drug use was observed (17.4% to 16.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), with a marked decrease in isolated Z\u2010drug use (6.1% to 4.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At baseline, use was associated with female sex (OR\u2009=\u20091.48; 95% CI 1.19\u20131.84), age 60\u201374\u2009years (OR\u2009=\u20091.64; 95% CI 1.29\u20132.10), having \u2265\u20092 fall\u2010related conditions (OR\u2009=\u20092.53; 95% CI 1.94\u20133.31), higher frailty scores, and cognitive dysfunction (OR\u2009=\u20091.32; 95% CI 1.00\u20131.74). Initiation was associated with pharmacist consultations during follow\u2010up (OR\u2009=\u20095.01; 95% CI 2.88\u20138.71), depression (OR\u2009=\u20092.59; 95% CI 1.80\u20133.73), insomnia (OR\u2009=\u20091.97; 95% CI 1.19\u20133.25), and panic syndrome. Pharmacist consultation was also associated with discontinuation (OR\u2009=\u20090.34; 95% CI 0.15\u20130.76).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical vulnerability and psychiatric conditions were associated with BZD or Z\u2010drug use and initiation, while pharmacist consultations were associated with both initiation and discontinuation trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70419","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:44:09Z","timestamp":1781934249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trajectories Associated With the Use and Deprescription of Benzodiazepines and\n                    <scp>Z<\/scp>\n                    \u2010Drugs in a Network of Geriatric 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