{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:02:37Z","timestamp":1784512957601,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Oxaliplatin\u2010based chemotherapy is the standard adjuvant treatment for stage III colon cancer, but oral fluoropyrimidines remain widely used for patients unsuitable for combination therapy. Real\u2010world data comparing these strategies are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of patients with stage III colon cancer who received adjuvant chemotherapy at Kaohsiung Veterans General Hospital (2017\u20132021). Using a 12\u2010month landmark design, we compared disease\u2010free survival (DFS) between patients receiving FOLFOX (IV\u2010Only) versus oral fluoropyrimidines (PO\u2010Only). The primary analysis used overlap\u2010weighted restricted mean survival time (RMST) differences to quantify absolute treatment effects. Cox proportional hazards regression provided complementary hazard ratio estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 157 patients included, 58 (36.9%) received FOLFOX and 99 (63.1%) received oral fluoropyrimidines. During median follow\u2010up of 36\u2009months, 22 DFS events occurred. The 3\u2010year DFS was 93.1% versus 76.5% for IV\u2010Only and PO\u2010Only groups, respectively. The primary analysis showed that patients receiving FOLFOX had 4.0 additional months of disease\u2010free time over 48\u2009months (RMST difference: 4.0\u2009months; 95% CI, 0.6\u20137.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and 2.4\u2009months over 36\u2009months (RMST difference: 2.4\u2009months; 95% CI, 0.2\u20134.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). The hazard ratio from overlap\u2010weighted Cox regression with covariate adjustment was 0.37 (95% CI 0.09\u20131.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.154), directionally consistent with the RMST findings but not reaching statistical significance. Hazard ratio estimates were directionally consistent across sensitivity analyses but varied in statistical significance, likely reflecting limited power: unadjusted (HR 0.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), stabilized weighting with covariates (HR 0.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046), and multivariable adjustment (HR 0.44;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.249).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, oral fluoropyrimidines were associated with 4.0 fewer months of disease\u2010free time compared with FOLFOX at 48\u2009months among patients for whom both treatment options were appropriate. As a single\u2010center study with limited events, these findings should be confirmed in larger multicenter cohorts. The combination of RMST with overlap weighting provides an interpretable framework for comparative effectiveness questions where treatment selection is strong.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70427","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:27:33Z","timestamp":1782923253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Effectiveness of Oral Fluoropyrimidines Versus\n                    <scp>FOLFOX<\/scp>\n                    as Adjuvant Therapy for Stage\n                    <scp>III<\/scp>\n                    Colon Cancer: A Retrospective Cohort Study Using Overlap\u2010Weighted Restricted Mean Survival Time Analysis"],"prefix":"10.1002","volume":"35","author":[{"given":"Shih\u2010Feng","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Wen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-4047","authenticated-orcid":false,"given":"Chih\u2010Chien","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsun","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032709"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.4238"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2974"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.6297"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(03)00399-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043116"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr366"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.05.025"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70486\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.13405"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.725"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.11.710"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.957951"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7819"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2016.1260466"},{"key":"e_1_2_11_17_1","volume-title":"Survey 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