{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:48:39Z","timestamp":1792205319098,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The pharmaco\u2010epidemiological research program in kidney transplantation (PERP\u2010KT) aims to evaluate, for the principal maintenance immunosuppressive drugs (MISDs): the influence of model\u2010informed precision dosing on graft and patient survival; long\u2010term exposure\u2014effects relationships; and the benefit\u2010harm balance of their combinations and time sequences in patient groups or clinical settings\u00a0not adequately evaluated in comparative randomized clinical trials. It also aims to develop a hybrid, dynamic, deep learning model capable of predicting the rate of renal graft function decline, thereby providing a platform for individualized prediction of the benefits and risks associated with MISDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>After obtaining all regulatory andd ethical approvals, de\u2010identified extracts of three national databases were linked to create the nationwide PERP\u2010KT dataset, which is hosted within the highly secure environment of\u00a0the French Health Data Hub.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CRISTAL (the exhaustive registry of the French Agence de la Biom\u00e9decine) comprises data from 49\u2009886 kidney donors and the corresponding 47\u2009842 transplant recipients between 2005 and 2020. Following iterative deterministic matching and extensive quality control procedures, CRISTAL data were successfully\u00a0linked to: the French national Health Data System (SNDS), which records reimbursed healthcare utilization,\u00a0for 30\u2009782 kidney transplant recipients; and to ISBA, a web\u2010based platform for Bayesian dose adjustment of MISDs\u00a0that contains pharmacological data, for 17\u2009700 kidney grafts and 17\u2009576 recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Perspectives<\/jats:title>\n                    <jats:p>More than 20 pharmaco\u2010epidemiological studies will leverage the database's extensive follow\u2010up, large population size and richness of clinical, healtcare\u2010utilization, and pharmacological data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70442","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:47:39Z","timestamp":1784875659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Pharmaco\u2010Epidemiological Research Program Leveraging a Nationwide Database of Kidney Transplantation"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-0760","authenticated-orcid":false,"given":"Pierre","family":"Marquet","sequence":"first","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-7254","authenticated-orcid":false,"given":"Antoine","family":"Humeau","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-391X","authenticated-orcid":false,"given":"Sabrina","family":"Cr\u00e9pin","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-7442","authenticated-orcid":false,"given":"Sylvain","family":"Couderc","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-5813","authenticated-orcid":false,"given":"Caroline","family":"Monchaud","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-8904","authenticated-orcid":false,"given":"Marc","family":"Labriffe","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9752-7313","authenticated-orcid":false,"given":"Franck","family":"Saint\u2010Marcoux","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Universit\u00e9 de Limoges, UMR1248 INSERM  Limoges France"},{"name":"Department of Pharmacology Toxicology and Pharmacovigilance, CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cRapport Scientifique Annuel de l'Agence de La Biom\u00e9decine \u201d2022 https:\/\/rams.agence\u2010biomedecine.fr\/greffe\u2010renale\u20100."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2023.01.009"},{"key":"e_1_2_11_4_1","unstructured":"S. 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M.Meyer et\u00a0al. \u201cLinking Data for Health Services Research: A Framework and Instructional Guide \u201d2014."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-1692-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad189"},{"key":"e_1_2_11_7_1","unstructured":"United States Renal Data System \u201cUnited States Renal Data System. 2025 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States \u201dKidney Transplant 2025 https:\/\/adr.usrds.org\/2025."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad281"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.185"},{"key":"e_1_2_11_10_1","unstructured":"NHS Blood and Transplant \u201cAnnual Report on Kidney Transplantation 2024\/25 \u201d2025 https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/37225\/nhsbt\u2010kidney\u2010transplantation\u2010report\u20102425.pdf."}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:49:59Z","timestamp":1791276599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/pds.70442"],"URL":"https:\/\/doi.org\/10.1002\/pds.70442","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70442"}}