{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:44:50Z","timestamp":1791945890190,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In 2014, TriNetX launched a U.S.\u2010based federated network of health system electronic health records (EHR) that is now used in academic and industry\u2010sponsored studies and includes more than 250 health care organizations (HCOs) globally. The network expanded to Latin America in 2018, where currently there are over 40 HCO partners in Brazil and Colombia. This manuscript describes the TriNetX LATAM Collaborative Network and outlines how it may support observational studies and clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried the LATAM Collaborative Network to determine patient counts for selected disease conditions. We used diagnosis codes, plus drug prescription and\/or biometric measures to estimate the frequency of diabetes, hypertension, heart failure, renal impairment, and chronic obstructive pulmonary disease, and estimated survival among patients with breast cancer and prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Approximately 4.54\u2009million patients had at least one healthcare encounter in the data system in 2025; 58.8% of them were female, and 30% were age 60 or older. About 1\u2009million adult patients had a diagnosis of hypertension, prescription of an angiotensin\u2010converting enzyme inhibitor or angiotensin II antagonist, or systolic blood pressure above 140\u2009mmHg. Among adult patients who had at least one serum estimated glomerular filtration test, 6.7% (43\u2009720 of 655\u2009560) had 2 instances of value &lt;\u200960\u2009mL\/min\/{1.73_m\n                      <jats:sup>2<\/jats:sup>\n                      } at least 3\u2009months apart. Among 166\u2009490 women with breast cancer, 5\u2010year survival was 90.7%. Among 116\u2009900 men with prostate cancer, 5\u2010year survival was 91.1%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TriNetX LATAM Collaborative Network represents an emerging, scalable EHR\u2010based data source to support pharmacoepidemiology studies and clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70459","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:44:47Z","timestamp":1789962287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TriNetX LATAM<\/scp>\n                    Collaborative Network, an\n                    <scp>EHR<\/scp>\n                    Data Source in Latin America"],"prefix":"10.1002","volume":"35","author":[{"given":"Vinicius","family":"Pinho","sequence":"first","affiliation":[{"name":"TriNetX LLC  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Tramujas","sequence":"additional","affiliation":[{"name":"Hcor Research Institute  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian","family":"Soares","sequence":"additional","affiliation":[{"name":"TriNetX LLC  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-8752","authenticated-orcid":false,"given":"Matvey B.","family":"Palchuk","sequence":"additional","affiliation":[{"name":"TriNetX LLC  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-1986","authenticated-orcid":false,"given":"K. 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