{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:58Z","timestamp":1789948918214,"version":"4.0.1"},"reference-count":122,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["Z\u20102021\u201046\u20102503"],"award-info":[{"award-number":["Z\u20102021\u201046\u20102503"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Deprescribing is increasingly recognized as an effective strategy for reducing potentially inappropriate medication (PIM) use and polypharmacy in older adults. However, existing deprescribing frameworks often lack detailed operational guidance, which may hinder their routine implementation in clinical practice. To systematically map and characterize the reported deprescribing processes in older adults with PIM use or polypharmacy and identify gaps in their operationalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase (Ovid), and Web of Science were comprehensively searched for studies describing deprescribing processes in older adults with PIM use or polypharmacy. The reported processes were evaluated against Reeve's patient\u2010centered deprescribing framework, which comprises five sequential steps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 92 studies describing deprescribing processes were included. Although 91 studies (98.91%) provided at least a partial description of the deprescribing process, only 1 study reported all five steps of Reeve's framework in detail. The step of planning and initiating medication withdrawal was the most frequently and thoroughly described (63\/92, 68.97%). In contrast, operational guidance for determining whether a medication could be ceased and prioritizing medications for discontinuation was rarely reported, with only 7 studies (7.61%) providing sufficient detail. Patient involvement in developing the deprescribing plan was also inconsistently reported, with nearly half of the studies inadequately addressing this aspect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Deprescribing processes are incompletely and inconsistently operationalized in the literature. In particular, guidance on cessation decisions, medication prioritization, and patient engagement remains limited. Future deprescribing frameworks should provide explicit, stepwise, and patient\u2010centered operational guidance to facilitate consistent implementation in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70467","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:20:46Z","timestamp":1787746846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Process of Deprescribing in Older Adults With Potentially Inappropriate Medication or Polypharmacy: A Scoping Review"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-5523","authenticated-orcid":false,"given":"Mengnan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Clinical Nutrition, Center of Clinical Epidemiology and Evidence\u2010Based Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-1564","authenticated-orcid":false,"given":"Zhaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-7520","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-0386","authenticated-orcid":false,"given":"Fangyuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101811"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.26910"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S190983"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0422-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa067"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glag176"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000587"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"issue":"2","key":"e_1_2_12_10_1","article-title":"Medication Review in Hospitalised Patients to Reduce Morbidity and Mortality","volume":"2","author":"Christensen M.","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.8274"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06089-2"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0354-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.16131"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15042"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13987"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1353-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12386"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2011.08.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-3991(02)00194-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2004.08.006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12732"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1575-8"},{"issue":"9","key":"e_1_2_12_26_1","first-page":"1291","article-title":"Efficacy of a Clinical Medication Review on the Number of Potentially Inappropriate Prescriptions Prescribed for Community\u2010Dwelling Elderly People","volume":"164","author":"Allard J.","year":"2001","journal-title":"CMAJ"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16273"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmaf064"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01073-6"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-015-0186-0"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098611400332"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/11584770-000000000-00000"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1585"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-024-02334-3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0558-7"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmw073"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.70269"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2020.05.026"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2020.07.010"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70399"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-016-0442-2"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2293-4"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16278"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-014-0157-5"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01895-z"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-026-07366-1"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16510"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.994819"},{"issue":"11","key":"e_1_2_12_49_1","first-page":"761","article-title":"A Randomized Study to Decrease the Use of Potentially Inappropriate Medications Among Community\u2010Dwelling Older Adults in A Southeastern Managed Care Organization","volume":"10","author":"Fick D. M.","year":"2004","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2019.1634323"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12993"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098618816562"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-021-03207-9"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.2015"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18867"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07728-6"},{"issue":"4","key":"e_1_2_12_57_1","first-page":"275","article-title":"Deprescribing Antihypertensive Treatment in Nursing Home Patients and the Effect on Blood Pressure","volume":"15","author":"Gulla C.","year":"2018","journal-title":"Journal of Geriatric Cardiology"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.22505"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-023-00403-0"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-025-02894-y"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020348"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.105122"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0602-3"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.23544"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac249"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610217000084"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1108\/IJHCQA-01-2017-0009"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.14699"},{"key":"e_1_2_12_69_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-074054","article-title":"Optimising Prescribing in Older Adults With Multimorbidity and Polypharmacy in Primary Care (Optica): Cluster Randomised Clinical Trial","volume":"381","author":"Jungo K. T.","year":"2023","journal-title":"BMJ"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150132719890227"},{"issue":"44","key":"e_1_2_12_71_1","first-page":"741","article-title":"Interprofessional Medication Management in Patients With Multiple Morbidities","volume":"113","author":"K\u00f6berlein\u2010Neu J.","year":"2016","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14557"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.03.012"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.26967"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-025-06122-1"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2020.1707082"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70194"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16078"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1263-3"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02612-0"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-023-01315-0"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15517"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003862"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.12931"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.7429"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12906"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igad042"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0057-0"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.4723"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH14219"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017740"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa072"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02727-9"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18650"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.24234"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.04.002"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149984"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104910"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1822"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afag029"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-025-01259-5"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.5096"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01582-4"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4871"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(24)00131-4"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.949"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04139-y"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019042"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.18549\/PharmPract.2020.4.2133"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002798"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2021.104391"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4281-3"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0895-z"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02507-0"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01870-8"},{"key":"e_1_2_12_116_1","first-page":"24","article-title":"Deprescribing Interventions for Older Patients: A Systematic Review and Meta\u2010Analysis","volume":"11","author":"Zhou D.","year":"2023","journal-title":"Journal of the American Medical Directors Association"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3310\/AAFO2475"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-061686"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.2307\/3349778"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200016060-00004"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61091-5"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-02753-w"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-022-01206-7"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:56:19Z","timestamp":1789948579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":122,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/pds.70467"],"URL":"https:\/\/doi.org\/10.1002\/pds.70467","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70467"}}