{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:58Z","timestamp":1789948918348,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Social media has propagated several \u201cchallenges\u201d that engage primarily adolescents in life\u2010threatening behaviors such as the \u201cBenadryl Challenge,\u201d where participants film themselves ingesting large doses of diphenhydramine. Once shared online, these activities have the potential to propagate, leading to an increase in those seeking emergency healthcare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study correlated call volume from poison centers with online mentions of the Benadryl Challenge. Data was collected from the National Poison Data System (NPDS) and the RADARS Web Monitoring Program across July 1\u2013December 31, 2020. The NPDS provided diphenhydramine\u2010related call volume across poison centers (PCs) and the RADARS Web Monitoring Program estimated the total number of online mentions related to the Benadryl Challenge across online platforms, blogs, forums, and news websites. Analysis utilized cross\u2010correlation statistics, identifying lead\u2013lag relationships between the datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cross\u2010correlation analysis revealed a reciprocal relationship with an increase in all diphenhydramine\u2010related calls predicting a consistent but not statistically significant increase in web mentions. Following the first increase in web mentions was a significantly associated increase in adolescent\u2010only related calls. The increase in PC calls was consistently elevated over baseline for over 25\u2009days following the spike in web mentions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PC call volume and web mentions demonstrate a reciprocal relationship and PC call volume remained elevated for over 25\u2009days after the spike in web mentions. Emergency services\/departments and public health efforts can be informed real\u2010time by these relationships as an early warning to healthcare facilities and professionals and may justify integration within these spaces to educate and prevent harm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70469","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:57:55Z","timestamp":1787745475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Web Monitoring as an Early Warning System: \u201cBenadryl Challenge\u201d Online Mentions Correlate With Diphenhydramine Overdoses Reported to\n                    <scp>US<\/scp>\n                    Poison Centers"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-6439","authenticated-orcid":false,"given":"Jacob","family":"Altholz","sequence":"first","affiliation":[{"name":"Rocky Mountain Poison and Drug Safety  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-7233","authenticated-orcid":false,"given":"Hannah","family":"St. Francis","sequence":"additional","affiliation":[{"name":"Kaiser Permanente San Francisco Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hoyte","sequence":"additional","affiliation":[{"name":"Rocky Mountain Poison and Drug Safety  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NBC Chicago \u201c13\u2010Year\u2010Old Dies After Doing What Family Says Was \u2018Benadryl Challenge\u2019 \u201d(2023) https:\/\/www.nbcchicago.com\/news\/local\/13\u2010year\u2010old\u2010dies\u2010after\u2010doing\u2010viral\u2010benadryl\u2010challenge\u2010what\u2010it\u2010is\u2010and\u2010what\u2010parents\u2010should\u2010know\/3122565\/."},{"key":"e_1_2_10_3_1","unstructured":"WTVG \u201cTwo Children in Bowling Green Overdose After \u2018Benadryl Challenge\u2019 \u201d(2026) https:\/\/www.13abc.com\/2026\/01\/22\/benadryl\u2010challenge\u2010causes\u2010two\u2010overdoses\u2010bg\/."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.15149"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.58226"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/pedsos.2025\u2010000573"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7141a4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020\u2010049536"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3671"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2014.944291"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycr.2022.100087"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.70469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.70469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:55:53Z","timestamp":1789948553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.70469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/pds.70469"],"URL":"https:\/\/doi.org\/10.1002\/pds.70469","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.177087971.18780960\/v1","asserted-by":"object"}]},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70469"}}