{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:26Z","timestamp":1789948886348,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To examine associations of current bladder antimuscarinic use with cognitive impairment in adults aged \u2265\u200975\u2009years with urinary symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed National Health and Nutrition Examination Survey 2011\u20132014 data. Current use was identified from medications reported during the previous 30\u2009days. Cognitive impairment was defined as CERAD delayed recall\u2009&lt;\u20095, animal fluency\u2009&lt;\u200914, or digit symbol substitution test\u2009&lt;\u200934 among available tests. Survey\u2010weighted logistic models estimated overall and age\u2010specific odds ratios (ORs); the primary model included demographic factors and KDM biological age acceleration. Missing KDM data were multiply imputed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 537 participants representing 8\u2009735\u2009786\u2009US adults, 34 reported current use and 375 met the cognitive\u2010impairment definition (weighted prevalence, 62.5%). The primary overall OR was 2.18 (95% confidence interval [CI], 0.93\u20135.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.069). The use\u2010by\u2010age interaction was imprecise (interaction OR, 0.21; 95% CI, 0.03\u20131.33;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.093). Among adults aged 75\u201379\u2009years, 10 of 12 users and 130 of 210 nonusers were impaired (weighted, 82.03% vs. 52.37%); the adjusted OR was 7.18 (95% CI, 1.11\u201346.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). Among adults in the public\u2010use group \u2265\u200980\u2009years, the OR was 1.18 (95% CI, 0.44\u20133.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.733).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The overall estimate was positive but imprecise, and the age\u2010specific contrast rested on sparse exposure. Because NHANES lacks prior\u2010use and discontinuation histories, results may reflect prescribing selection and do not support causal or age\u2010threshold treatment inferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70479","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:17:08Z","timestamp":1789431428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bladder Antimuscarinic Use and Cognitive Impairment in Adults Aged 75\u2009Years or Older With Urinary Incontinence or Overactive Bladder Symptoms: A Population\u2010Based Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Renjie","family":"Huang","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Heilongjiang University of Chinese Medicine  Harbin 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