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L\u2010type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated whether brain penetrant (BP)\u2010LTCCBs are associated with reduced alcohol consumption in two preregistered observational cohort studies using electronic health records from the US Department of Veterans Affairs (VA) and Kaiser Permanente Northern California (KPNC). New users of BP\u2010LTCCBs (nifedipine or felodipine) were compared with new users of a non\u2010BP\u2010LTCCB (amlodipine) and with unexposed patients from the same clinics, requiring a 180\u2010day washout and \u2265\u200960\u2009days' supply. Propensity score matching was performed across all exposure contrasts. The primary outcome was change in drinks per week from pre\u2010index to end of follow\u2010up using difference\u2010in\u2010differences (DiD) models, with prespecified subgroup analyses by AUD diagnosis, drinking level, and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across both health systems, BP\u2010LTCCB initiation was not associated with greater reductions in drinks per week than either comparator, with broadly consistent findings across all subgroups; though some subgroups were small and imprecise. In the VA, the DiD comparing BP\u2010LTCCB with non\u2010BP\u2010LTCCB was 0.14 drinks\/week (95% CI \u22120.06, 0.34), and versus unexposed was 0.00 (95% CI \u22120.18, 0.19). Similar results were observed in KPNC (BP\u2010LTCCB vs. non\u2010BP\u2010LTCCB: 0.31, 95% CI \u22120.48, 1.11; BP\u2010LTCCB vs. unexposed: 0.16, 95% CI \u22120.67, 0.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In two large, preregistered EHR\u2010based cohorts, we found no evidence that BP\u2010LTCCBs were associated with reduced drinking relative to comparators. Despite compelling genetic and preclinical evidence, these findings do not support repurposing BP\u2010LTCCBs for AUD and instead prioritize alternative pharmacologic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70487","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:09:45Z","timestamp":1790564985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-7907","authenticated-orcid":false,"given":"Christopher T.","family":"Rentsch","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Faculty of Epidemiology and Population Health London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-579X","authenticated-orcid":false,"given":"Vanessa A.","family":"Palzes","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Research, Division of Research Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-9822","authenticated-orcid":false,"given":"Mingjian","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Uniformed Services University of the Health Sciences  Bethesda Maryland USA"},{"name":"Henry M. 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