{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:00Z","timestamp":1791945900310,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Intussusception is a serious condition and a rare adverse event of rotavirus vaccination. While health insurance claims data are increasingly used for epidemiological research, claims\u2010based algorithms for identifying intussusception have not been validated in Japan. This study aimed to validate multiple claims\u2010based algorithms for intussusception identification against ultrasound findings as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This validation study used claims data and ultrasound findings from three Japanese hospitals between 2011 and 2024. The study population comprised all patients who received care during each hospital's data period. We developed 10 algorithms combining an intussusception diagnostic code (ICD\u201010: K56.1), hospitalization status, ultrasound imaging codes, and surgery codes. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each algorithm. Age\u2010 and sex\u2010stratified analyses were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 701\u2009263 patients (mean age: 41.8\u2009years; 52.0% female), 79 true intussusception cases (mean age: 8.3\u2009years; 41.8% female) were identified (prevalence: 0.0113%). While sensitivity (54.4%\u201377.2%) and PPV (8.9%\u201328.1%) varied according to definition stringency, all algorithms achieved near\u2010perfect specificity and NPV (\u2265\u200999.9%). The algorithm that only used the diagnostic code yielded the highest sensitivity, while the algorithm that incorporated all four criteria achieved the highest PPV. Algorithm validity varied by age, with higher sensitivity and PPV for children aged \u2264\u20095\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The algorithms demonstrated a trade\u2010off between sensitivity and PPV, and researchers should select algorithms according to their study objectives. Our findings provide a robust foundation to guide algorithm selection for intussusception research using Japanese claims data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70488","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:32:13Z","timestamp":1790677933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Claims\u2010Based Algorithms for Intussusception Identification in Japanese Hospitals: A Multicenter Analysis From the\n                    <scp>CLEAR<\/scp>\n                    Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9621-1440","authenticated-orcid":false,"given":"Kumiko","family":"Saito","sequence":"first","affiliation":[{"name":"Public Health Informatics Unit, Department of Integrated Health Sciences Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Laboratory of Clinical Epidemiology, Department of Data Science, Center for Clinical Sciences Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1302-9430","authenticated-orcid":false,"given":"Chieko","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Epidemiology, Department of Data Science, Center for Clinical Sciences Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-9171","authenticated-orcid":false,"given":"Kazuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Nursing for Advanced Practice, Department of Integrated Health Sciences Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-4837","authenticated-orcid":false,"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[{"name":"Public Health Informatics Unit, Department of Integrated Health Sciences Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-1548","authenticated-orcid":false,"given":"Haruhisa","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.09.055"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010023\u201003961\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20106723.2007.00923.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u201012\u201036"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268805004644"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.088"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000000715"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1197452"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit520"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200102223440804"},{"key":"e_1_2_11_12_1","unstructured":"WHO \u201cRotavirus Vaccines and Intussusception \u201dGlobal Advisory Committee on Vaccine Safety. 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