{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:49:54Z","timestamp":1759837794557},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,6]],"date-time":"2002-06-06T00:00:00Z","timestamp":1023321600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare levels of recorded risk factors and drug treatment between patients with validated and non\u2010validated diagnoses of coronary heart disease (CHD) in Northern Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a nitrate prescription in the previous year or a CHD Read code were identified from computer records of 25 practices, stratified by partnership size and area board. Computer and paper records of a random sample of 10% of these were searched for specified criteria to validate the diagnosis of CHD. The diagnosis was considered valid if the patient was found to have one or more positive investigations for CHD. Records of blood pressure, cholesterol, blood sugar, body mass index and drugs prescribed were taken into account.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combined practice population was 151\u2009071; 7338 (4.86%) were identified by the computer search as meeting the defined entry criteria for CHD. Among the 10% random sample the diagnosis of CHD could not be validated for 36.5% (265\/727). Significantly more patients with a validated than non\u2010validated diagnosis had recorded cholesterol levels below 5.0\u2009mmol\/l (55.8 vs. 34.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and were prescribed aspirin (75.3 vs. 40.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), beta\u2010blockers (51.5 vs. 28.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), angiotensin\u2010converting\u2010enzyme inhibitors (29.2 vs. 15.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and lipid\u2010lowering drugs (50.9 vs. 23.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A recent nitrate prescription had a higher predictive value for validated CHD than a Read code for CHD alone (71.2 vs. 53.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No other significant differences were found between the two groups regarding the extent or levels of recorded risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with a validated diagnosis of CHD appear to be better managed than those whose diagnosis has not been confirmed. Validation of diagnosis has important implications for assessing the provision of secondary prevention and for clinical governance. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.709","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:35:39Z","timestamp":1033907739000},"page":"311-317","source":"Crossref","is-referenced-by-count":9,"title":["The importance of validating the diagnosis of coronary heart disease when measuring secondary prevention: a cross\u2010sectional study in general practice"],"prefix":"10.1002","volume":"11","author":[{"given":"Paul","family":"Connolly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Cupples","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazel","family":"Cuene\u2010Grandidier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Passmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,6]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"National Service Framework for Coronary Artery Disease: Modern Standards and Service Models","author":"Department of Health","year":"2000"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7300.1463"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7290.832"},{"key":"e_1_2_1_5_2","first-page":"181","article-title":"Completeness and accuracy of morbidity and repeat prescribing records held on general practice computers in Scotland","volume":"46","author":"Whitelaw FG","year":"1996","journal-title":"Br J Gen Pract"},{"key":"e_1_2_1_6_2","first-page":"537","article-title":"Assessment of the completeness and accuracy of computer medical records in four practices committed to recording data on computer","volume":"45","author":"Pringle M","year":"1995","journal-title":"Br J Gen Pract"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7299.1401"},{"key":"e_1_2_1_8_2","first-page":"706","article-title":"An assessment of morbidity registers for coronary heart disease in primary care","volume":"50","author":"Moher M","year":"2000","journal-title":"Br J Gen Pract"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1635"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7344.1016"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351401"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117386"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/eurheartj\/14.suppl_F.18","article-title":"Effect of beta\u2010blockers and calcium channel blockers in acute myocardial infarction","volume":"14","author":"Held PH","year":"1993","journal-title":"Eur Heart J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-5-199509010-00007"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7200.1730"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90865-X"},{"key":"e_1_2_1_17_2","first-page":"1115","article-title":"Gruppo Italiano per lo Studio della Sopravvivienzanell'infarto Miocardico. 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