{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:04:11Z","timestamp":1791198251776,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T00:00:00Z","timestamp":1054598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Experimental evidence raises the possibility that acetaminophen use could reduce the risk of myocardial infarction (MI). We assessed the relation of acetaminophen use, and also of aspirin use, to first MI in a case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on analgesic use and other factors were collected in a hospital\u2010based case\u2010control study of first MI in men under 55 years of age conducted from 1980 to 1983. We compared 2035 men with first MIs to 2656 control men admitted for conditions unrelated to analgesic use. Odds ratios (ORs) for acetaminophen use relative to nonuse were estimated with logistic regression analysis, controlling for major MI risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The OR was 0.9 (95% confidence interval (CI): 0.6\u20131.3) for acetaminophen use at least once a week for at least 3 months, 0.7 (95%CI: 0.4\u20131.1) for daily use for at least 3 months, and 0.5 (95%CI: 0.2\u20131.6) for daily use for at least 5 years. In analyses of aspirin use, the OR was 0.9 (95%CI: 0.7\u20131.2) for use at least once a week for at least 3 moths, 0.9 (95%CI: 0.6\u20131.2) for daily use lasting at least 3 months, 0.6 (95%CI: 0.4\u20131.1) for daily use for at least 5 years, and 0.4 (95%CI: 0.2\u20131.0) for daily use for at least 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While our results raise the possibility of a protective effect of long\u2010term regular acetaminophen use against first MI, they are compatible with no effect. The data suggest a potential protective effect of long\u2010term regular aspirin use. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.867","type":"journal-article","created":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T19:33:38Z","timestamp":1062531218000},"page":"459-465","source":"Crossref","is-referenced-by-count":16,"title":["A case\u2010control study of acetaminophen use in relation to the risk of first myocardial infarction in men"],"prefix":"10.1002","volume":"12","author":[{"given":"Lynn","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Sowmya","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904063201407"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.9.1338"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)90873-0"},{"key":"e_1_2_1_5_2","first-page":"348","article-title":"Inhibition of fatty streak formation and lipid oxidation by low doses of acetaminophen in hypercholesterolemic rabbits","volume":"54","author":"Rogers LK","year":"2000","journal-title":"Toxicol Sci"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2855"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00119-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"H2631","DOI":"10.1152\/ajpheart.2001.280.6.H2631","article-title":"Coronary and myocardial effects of acetaminophen: protection during ischemia\u2010reperfusion","volume":"280","author":"Merrill G","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003950170023"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00716.2001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/oxfordjournals.aje.a114333","article-title":"The risk of myocardial infarction a decade or more after vasectomy in men under 55 years of age","volume":"123","author":"Rosenberg L","year":"1986","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_12_2","unstructured":"Ischaemic Heart Disease Registers.Report of the Fifth Working Group. 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