{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:21:30Z","timestamp":1791426090924,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T00:00:00Z","timestamp":1063584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the extent of doctor\u2010shopping for buprenorphine maintenance therapy in a French region with a specific indicator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Use of a quasi\u2010exhaustive prescription database in a French region (information system of the French General Health Insurance Scheme). Extraction of all buprenorphine prescriptions between September 1999 and December 2000. Definition and calculation of three quantities for each patient: delivered, prescribed and doctor\u2010shopping quantity. The calculation of these three quantities is done by an automated and reproducible method determining the overlaps in prescription periods of different physicians for a given patient. Calculation of the corresponding daily dose was done for each quantity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64\u2009326 prescriptions of buprenorphine by 1313 physicians to 3259 patients were extracted. Quantities and doses were calculated for 2587 patients. The total doctor\u2010shopping quantity represented 18.6% of the delivered quantity. Doctor\u2010shopping involved a minority of patients and was highly concentrated: 87 patients with doctor\u2010shopping doses superior to 16\u2009mg\/day were responsible for 45.4% of the total doctor\u2010shopping quantity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Doctor\u2010shopping appears to be an important problem for buprenorphine maintenance treatment in France but may be resolved by regulatory interventions. The use of adequate indicators on prescription databases may help to limit the effects of such interventions on legitimate care. The method presented here may be used with slight adaptations for other medications to assess their abuse potential. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.892","type":"journal-article","created":{"date-parts":[[2004,7,16]],"date-time":"2004-07-16T10:03:49Z","timestamp":1089972229000},"page":"473-481","source":"Crossref","is-referenced-by-count":74,"title":["Assessment of doctor\u2010shopping for high dosage buprenorphine maintenance treatment in a French region: development of a new method for prescription database"],"prefix":"10.1002","volume":"13","author":[{"given":"Vincent","family":"Pradel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Thirion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9onore","family":"Ronfle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Masut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Micallef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"B\u00e9gaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,15]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Observatoire Fran\u00e7ais des Drogues et des Toxicomanies (OFDT). Drogues et d\u00e9pendances: Indicateurs et tendances \u2010 \u00e9dition 2002. OFDT: Paris 2002;156\u2013157."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(01)00161-2"},{"issue":"3","key":"e_1_2_1_4_2","first-page":"IS5","article-title":"Diminution du nombre de surdoses mortelles a l'h\u00e9ro\u00efne, en France, depuis 1994. A propos du r\u00f4le des traitements de substitution","volume":"152","author":"Lepere B","year":"2001","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2001.96226710.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(01)00454-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(96)00402-9"},{"key":"e_1_2_1_8_2","first-page":"1552","article-title":"Traitement de substitution par bupr\u00e9norphine haut dosage","volume":"121","author":"Cholley D","year":"1999","journal-title":"Concours Med"},{"key":"e_1_2_1_9_2","first-page":"21","article-title":"Suivi sur trois ans d'une population de malades d\u00e9pendants aux opiac\u00e9s","volume":"3","author":"Spoerry A","year":"2000","journal-title":"Revue M\u00e9dicale de l'Assurance Maladie"},{"key":"e_1_2_1_10_2","first-page":"2133","article-title":"Subutex: attention aux patients nomades et aux coprescriptions de benzodiaz\u00e9pines !","volume":"517","author":"Fumeau B","year":"2000","journal-title":"Rev Prat Med Gen"},{"key":"e_1_2_1_11_2","first-page":"311","article-title":"Traitement de substitution par la bupr\u00e9norphine\u2010haut\u2010dosage en m\u00e9decine de ville en Aquitaine","volume":"32","author":"Damon MN","year":"2001","journal-title":"Revue M\u00e9dicale de l'Assurance Maladie"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(01)00189-1"},{"issue":"4","key":"e_1_2_1_13_2","first-page":"295","article-title":"Traitement de substitution par bupr\u00e9norphine\u2010haut\u2010dosage: quel r\u00f4le pour l'assurance maladie?","volume":"32","author":"Cholley D","year":"2001","journal-title":"Revue M\u00e9dicale de l'Assurance Maladie"},{"issue":"4","key":"e_1_2_1_14_2","first-page":"305","article-title":"Traitement de substitution par bupr\u00e9norphine\u2010haut\u2010dosage une exp\u00e9rience de suivi","volume":"32","author":"Excler\u2010Cavailher G","year":"2001","journal-title":"Revue M\u00e9dicale de l'Assurance Maladie"},{"key":"e_1_2_1_15_2","unstructured":"PalleC TellierS.Les usagers de drogues illicites pris en charge par le syst\u00e8me de soins en novembre 1997 Etudes et R\u00e9sultats. DREES 59: Paris2000."},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"SPSS for Windows Rel. 11.0.1. 2001. SPSS: Chicago Inc.","DOI":"10.1007\/978-3-322-93157-3_1"},{"key":"e_1_2_1_17_2","first-page":"325","article-title":"The impact of prescription drug control systems on medical practice and patient care\u2014a summary of research recommendations","volume":"131","author":"Czechowicz D","year":"1993","journal-title":"NIDA Research Monograph"},{"key":"e_1_2_1_18_2","first-page":"206","article-title":"Summary and conclusions of a review of prescription drug diversion control methods","volume":"131","author":"Horgan C","year":"1993","journal-title":"NIDA Research Monograph"},{"key":"e_1_2_1_19_2","first-page":"145","article-title":"Diversion investigation units\u2014methods, utilities, and limitations","volume":"131","author":"Bulla R","year":"1993","journal-title":"NIDA Research Monograph"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1081\/JA-100106227"},{"key":"e_1_2_1_21_2","first-page":"175","article-title":"Contribution \u00e0 l'\u00e9valuation de la politique de r\u00e9duction des risques: le syst\u00e8me SIAMOIS","volume":"2","author":"Emmanuelli J","year":"1998","journal-title":"Bull Epidemiol Annu"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpds.892","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T21:19:36Z","timestamp":1700169576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,15]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/pds.892"],"URL":"https:\/\/doi.org\/10.1002\/pds.892","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,15]]}}}