{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:49:20Z","timestamp":1785426560512,"version":"3.56.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Acute <jats:italic>Mycoplasma pneumoniae<\/jats:italic> bronchiolitis can progress into bronchiolitis obliterans (<jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>) in children, which has a major influence on a child's quality of life and is associated with <jats:italic>M. pneumoniae<\/jats:italic> bronchiolitis. Early identification and treatment of <jats:italic>M. pneumoniae<\/jats:italic> bronchiolitis is important to prevent the development of <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To enhance the understanding of the diagnosis and treatment of <jats:italic>M. pneumoniae<\/jats:italic> bronchiolitis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight patients with <jats:italic>M. pneumoniae<\/jats:italic> bronchiolitis were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of the patients with <jats:italic>M. pneumoniae<\/jats:italic> bronchiolitis were male and three of them were female. All patients suffered from fever and cough. Moist rales and wheezing were noted in both lungs in six patients. High\u2010resolution computed tomography of the chest showed bronchiolitis in all patients, with large airway injury in two and focal bronchopneumonia in six. Two patients were confirmed to have asthma. Seven patients had personal and\/or family histories of atopic diseases. Allergen testing was performed in six patients, which produced positive results in four; the remaining two patients had negative results, but their total IgE levels were &gt; 200 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/ml. Azithromycin therapy and glucocorticoid therapy was administered to all eight patients. One patient required noninvasive ventilation. Treatment of all patients was successful, with no development of bronchiolitis obliterans during the 4\u2010 to 8\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p><jats:italic>Mycoplasma pneumoniae<\/jats:italic> bronchiolitis can occur in children, especially in atopic individuals. The use, time of initiation, and effects of glucocorticoids administration in these patients for the prevention of <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content> require further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12108","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:18:27Z","timestamp":1547021907000},"page":"248-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicoradiologic features of <i>Mycoplasma pneumoniae<\/i> bronchiolitis in children"],"prefix":"10.1002","volume":"2","author":[{"given":"Xiaohui","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100473"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08861-7"},{"key":"e_1_2_6_4_1","first-page":"1277","article-title":"Acute bronchiolitis due to Mycoplasma pneumoniae and successfully treated with steroids","volume":"34","author":"Mashimoto H","year":"1996","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.11150\/kansenshogakuzasshi1970.81.586","article-title":"A case of mycoplasmal pneumonia with bronchiolitis treated with steroids","volume":"81","author":"Iwata A","year":"2007","journal-title":"Kansenshogaku Zasshi"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.1188"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000208455.80725.2a"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.4187\/respcare.01613","article-title":"Mycoplasma pneumoniae bronchiolitis mimicking asthma in an adult","volume":"57","author":"Vasudevan VP","year":"2012","journal-title":"Respir Care"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.11150\/kansenshogakuzasshi1970.74.259","article-title":"Two cases of hypoxemic acute bronchiolitis due to Mycoplasma pneumoniae","volume":"74","author":"Kawamoto M","year":"2000","journal-title":"Kansenshogaku Zasshi"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.rmr.2013.03.005","article-title":"Acute respiratory failure due to Mycoplasma pneumonia","volume":"30","author":"Patout M","year":"2013","journal-title":"Rev Mal Respir"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rmedx.2007.01.011","article-title":"Mycoplasma pneumoniae causing familial infection and acute severe respiratory failure","volume":"3","author":"Pataka A","year":"2007","journal-title":"Respir Med Extra"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/00365540902942840","article-title":"Mycoplasma pneumoniae bronchiolitis in adults: clinicoradiologic features and clinical course","volume":"41","author":"Cha SI","year":"2009","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00695"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fped4.12108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T17:54:34Z","timestamp":1694454874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/ped4.12108"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12108","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2017-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}