{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:09:39Z","timestamp":1746623379281},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>Importance<\/jats:title>The use of the rapid antigen\u2010detection test (RADT<\/jats:styled-content>) has become the standard of care in the early diagnosis of group A beta\u2010hemolytic Streptococcus<\/jats:italic> (GAS<\/jats:styled-content>) pharyngitis. Concern has been expressed over increased false positives when the child had been treated recently for GAS<\/jats:styled-content> pharyngitis, resulting in over use of antibiotics.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine if the false positive rate for RADT<\/jats:styled-content> is increased in children recently treated for GAS<\/jats:styled-content> pharyngitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a prospective study to evaluate 300 children from a private practice with acute pharyngitis who were treated for GAS<\/jats:styled-content> pharyngitis within the preceding 28 days (study group) compared to 306 children of comparable age who had not been previously treated (control group). RADT<\/jats:styled-content> and throat culture were performed on all children presenting with signs and symptoms of acute pharyngitis. The false positive and false negative rates were determined and compared in both groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The false positive rate of 11.5% (23\/200) in the study group was significantly higher than the false positive rate of 0 in the control group. False positives were more likely to occur in younger children.<\/jats:p><\/jats:sec>Interpretation<\/jats:title>These data would indicate that while RADT<\/jats:styled-content> is reliable in most children, it can lead to over treatment in children who have been recently treated for GAS<\/jats:styled-content>. In children treated in the preceding 28 days for GAS<\/jats:styled-content> pharyngitis, the presence of infection should be determined with a throat culture only. Treatment based on a positive RADT<\/jats:styled-content> should be reserved for children not recently treated for GAS<\/jats:styled-content> pharyngitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12109","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T11:46:06Z","timestamp":1553255166000},"page":"27-30","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid strep testing in children with recently treated streptococcal pharyngitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Amin J.","family":"Barakat","sequence":"first","affiliation":[{"name":"Georgetown University Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coni","family":"Evans","sequence":"additional","affiliation":[{"name":"Northern Virginia Pediatric Associates Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Gill","sequence":"additional","affiliation":[{"name":"Children's Medical Associates of Northern Virginia Alexandria VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Nelson","sequence":"additional","affiliation":[{"name":"Georgetown University Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.3.571-580.2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.267.5.695"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70213-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170280015002"},{"key":"e_1_2_7_6_1","first-page":"261","article-title":"Accuracy of rapid strep testing in patients who have had recent streptococcal pharyngitis","volume":"15","author":"Sheeler RD","year":"2002","journal-title":"J Am Board Fam Pract"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.924"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.6.5.761"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(54)80008-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810376235"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ped4.12109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:32:21Z","timestamp":1694421141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/ped4.12109"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12109","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"2018-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}