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Herein, we review the reported cases that manifest with both gonad dysplasia and <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>. Further, we examine the hypothesis that these patients exhibit a normal hypothalamic\u2010pituitary\u2010gonadal axis, hypogonadism, and the presence of residual gonadal function, and that the onset of disease is related to early initiation of the hypothalamic\u2010pituitary\u2010gonadal axis. Thus, we suggest that <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> is a prelude of some partial hypogonadism.<\/jats:p>","DOI":"10.1002\/ped4.12118","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T11:46:06Z","timestamp":1553255166000},"page":"50-54","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Central precocious puberty as a prelude of gonad dysplasia"],"prefix":"10.1002","volume":"3","author":[{"given":"Lele","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology Genetics, Metabolism and Adolescent Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Genetics, Metabolism and Adolescent 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