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For each group, we firstly used an in vivo microdialysis technique to investigate the concentrations of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>; and secondly, we recorded the neural activity in the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> using a single\u2010unit recording technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> concentration in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group significantly increased after <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> injection, whereas that of the saline group did not change. The <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> concentration in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>+Lido group also showed an increasing trend but was significantly lower than that in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group. In the electrophysiological study, the spontaneous firing rate of the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group was significantly higher than that of the saline group. In addition, the proportion of short interval discharges was also higher in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group than in the saline group. Both differences were reversed by lidocaine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our data suggest that the elevation of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> levels in the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> may be related to increased neuronal activity, which may represent the mechanism underlying salicylate\u2010induced tinnitus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12143","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T11:12:05Z","timestamp":1569496325000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salicylate increased ascorbic acid levels and neuronal activity in the rat auditory cortex"],"prefix":"10.1002","volume":"3","author":[{"given":"Qingchuan","family":"Duan","sequence":"first","affiliation":[{"name":"Department of 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