{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:48:05Z","timestamp":1792018085661,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z151100004015159"],"award-info":[{"award-number":["Z151100004015159"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>There is a high incidence of iron deficiency in children worldwide. Notably, however, while iron deficiency is the most common cause of anemia, little is known about the prevalence and different types of iron deficiency in neuroblastoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to investigate the prevalence of iron deficiency in patients newly diagnosed with neuroblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 195 newly diagnosed neuroblastoma patients from November 2015 to January 2018 were analyzed retrospectively. The survival analysis was estimated by the Kaplan\u2010Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 195 neuroblastoma patients included in the study, 121 (62.1%) had iron deficiency, 55 (28.2%) had absolute iron deficiency, and 66 (33.9%) had functional iron deficiency. Being aged \u2265 18 months, tumor originating in the abdomen, International Neuroblastoma Risk Group Staging System M, high\u2010risk neuroblastoma, lactate dehydrogenase \u2265 1500 U\/L, neuron\u2010specific enolase \u2265 100 U\/L, unfavorable histologic category, <jats:italic>MYCN<\/jats:italic> amplification, chromosome 1p loss, and bone marrow metastasis were associated with significantly higher rates of functional iron deficiency (<jats:italic>P &lt;<\/jats:italic> 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Functional iron deficiency at the time of initial neuroblastoma diagnosis predicted lower event\u2010free survival. Long\u2010term effects of iron supplementation in neuroblastoma patients with different types of iron deficiency need to be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12156","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T17:34:37Z","timestamp":1572111277000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Iron deficiency in children at the time of initial neuroblastoma diagnosis"],"prefix":"10.1002","volume":"4","author":[{"given":"Hongjun","family":"Fan","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology National Discipline of Pediatrics Ministry of Education MOE Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health Beijing 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