{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:58:00Z","timestamp":1768035480237,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Nasal nitric oxide (<jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content>) testing is a method used in the diagnosis of primary ciliary dyskinesia (<jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>). It has not been evaluated in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish a reference <jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> value to assist in the diagnosis of <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> in Chinese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> values were measured in children with <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> (<jats:italic>n =<\/jats:italic> 36), cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) (<jats:italic>n =<\/jats:italic> 20), asthma (<jats:italic>n =<\/jats:italic> 45), post\u2010infectious bronchiolitis obliterans (<jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>) (<jats:italic>n =<\/jats:italic> 41) and non\u2010<jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>\/non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis (<jats:italic>n =<\/jats:italic> 32). The receiver operating characteristic <jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> value for the diagnosis of <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> was plotted and the area under the curve was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> values were significantly lower in children with <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> (median 25.66 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min) than in children with asthma (186.26 \u00b1 58.95 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/ min), <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content> (143.47 \u00b1 49.71 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min) and non\u2010<jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>\/non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis (173.13 \u00b1 63.80 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min), but not in children with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> (90.90 \u00b1 43.20 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min). Notably however, no <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patient had an <jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> value &lt; 45 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min. A cut\u2010off of 76 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min yielded the best sensitivity of 86.1%, and specificity of 91.4%, with an area under the curve of 0.920 (95% confidence interval 0.859\u20130.981) for the diagnosis of <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>. If <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> was ruled out the specificity increased to nearly 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> testing is able to discriminate between patients with <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> and those with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>, asthma, post\u2010infectious <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>\/non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis. A cut\u2010off of 76 <jats:styled-content style=\"fixed-case\">nL<\/jats:styled-content>\/min could be further examined in patients suspected of <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>, to establish an <jats:styled-content style=\"fixed-case\">nNO<\/jats:styled-content> reference value for <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content> screening in Chinese children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12160","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T18:38:26Z","timestamp":1576953506000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The value of nasal nitric oxide measurement in the diagnosis of primary ciliary dyskinesia"],"prefix":"10.1002","volume":"3","author":[{"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[{"name":"The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinglan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunying","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181a53562"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01090-2016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201805-0819ST"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0147-3"},{"key":"e_1_2_6_6_1","first-page":"1184","article-title":"Accuracy of nasal nitric oxide measurement as a diagnostic test for primary ciliary dyskinesia. A systematic review and meta\u2010analysis","volume":"14","author":"Shapiro AJ","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00305503"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.11.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20344"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.586"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13a22.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00068810"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00015205"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1054"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2015.09.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00032610"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00068810"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.71"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fped4.12160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ped4.12160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T16:08:29Z","timestamp":1694189309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/ped4.12160"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12160","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}