{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:30:12Z","timestamp":1790667012284,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Cancer is the main cause of death by disease in children. Children experience the highest incidence of cancer in the first year of life. However, there is no comprehensive registration system for children with tumors in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing, China, thereby providing evidence to guide further clinical research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 1, 2010 to December 31, 2019, patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing. The epidemiology, clinical features, and therapeutic effects of tumors in these patients were analyzed retrospectively. All patients were followed up until March 31, 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 938 patients were enrolled in this study. There were 530 boys (56.5%) and 408 girls (43.5%); the median age was 6.0 months (range, 0\u201312.0 months). The three most common tumors were retinoblastoma in 366 patients (39.0%), neuroblastoma in 266 patients (28.4%), hepatoblastoma in 133 patients (14.2%), and central nervous system tumors in 52 patients (5.5%). The estimated 5\u2010year overall survival rate was 81.3% \u00b1 1.8%, and the 5\u2010year event\u2010free survival rate was 71.8% \u00b1 2.9%. The 5\u2010year overall survival rates of non\u2010rhabdomyosarcoma soft tissue sarcoma, neuroblastoma, and retinoblastoma were 100%, 88% \u00b1 2.2%, and 86.9% \u00b12.1%, respectively. The 5\u2010year event\u2010free survival rates were 81.1% \u00b1 2.7% for neuroblastoma, 81.6% \u00b1 9.8% for non\u2010rhabdomyosarcoma soft tissue sarcoma, and 72.7% \u00b1 14.1% for extracranial malignant germ cell tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The three most common infantile malignant solid tumors were retinoblastoma, neuroblastoma, and hepatoblastoma. Multidisciplinary combined diagnosis and treatment is needed for infantile tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12213","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T16:39:41Z","timestamp":1601224781000},"page":"178-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnosis and treatment of infantile malignant solid tumors in beijing, China: A multicenter 10\u2010year retrospective study"],"prefix":"10.1002","volume":"4","author":[{"given":"Mei","family":"Jin","sequence":"first","affiliation":[{"name":"Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital Capital Medical University  Beijing 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