{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:59:51Z","timestamp":1771329591460,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Cleft lip and palate (CLP) is globally among the most common childhood malformations. This disorder impacts childhood development, including speech and language, and affects children worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze child development skills (adaptive fine motor, gross motor, personal\u2010social, and language) in preschool children with isolated CLP compared with children without this malformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The participants included an experimental group of 27 children with isolated CLP and a comparison group of 27 children without CLP aged between 48 and 59 months. The groups were evaluated using two instruments: the Denver Developmental Screening Test II (DDST\u2010II) and the Avalia\u00e7\u00e3o do Desenvolvimento da Linguagem (ADL\u2010Language Development Assessment). Data were analyzed by descriptive and inductive analyses, using the Student\u2019s <jats:italic>t<\/jats:italic>\u2010test and the Mann\u2010Whitney test, at a significance level of <jats:italic>P<\/jats:italic> <jats:italic>\u02c2<\/jats:italic> 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All children in the comparison group performed within normal standards for their age range in the DDST\u2010II and the ADL. The worst performance in the experimental group was observed in language skills, followed, in declining order, by adaptive fine motor, personal\u2010social, and gross motor as measured by the DDST\u2010II. Children with isolated CLP also performed poorly in receptive, expressive, and global language in the ADL. No statistically significant differences were observed in the experimental group\u2019s scores for the ADL and the DDST\u2010II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Developmental skill levels were below expectations for children of this age with isolated CLP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12250","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T15:09:10Z","timestamp":1616425750000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Global and communicative development skills in preschool children with cleft lip and palate"],"prefix":"10.1002","volume":"5","author":[{"given":"Mayalle Rocha Bonfim","family":"Jurado","sequence":"first","affiliation":[{"name":"Department of Speech\u2010Language Pathology and Audiology Bauru School of Dentistry University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriela","family":"Cavalheiro","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"de Castro Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Plateau University Center of the Federal District UNIPLAN  Brasilia Distrito Federal Brazil"},{"name":"University of Bras\u00edlia UnB  Brasilia Distrito Federal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina Evangelista","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Rocha","family":"de Vasconcelos Hage","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology and Audiology Bauru School of Dentistry University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dion\u00edsia Aparecida Cusin","family":"Lam\u00f4nica","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology and Audiology Bauru School of Dentistry University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Paula","family":"Maximino","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology and Audiology Bauru School of Dentistry University of S\u00e3o Paulo  Bauru SP Brazil"},{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"63","article-title":"Cleft palate speech and velopharyngeal dysfunction: the approach of the speech therapist","volume":"2","author":"De Bodt M","year":"2006","journal-title":"B\u2010ENT"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2002)039<0157:TIOEPO>2.0.CO;2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-213"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.05.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2000)037<0348:SALIIT>2.3.CO;2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0145"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13682820110074999"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/05-164"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.10.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000450639"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1358582"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817703926"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.08.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699206.2013.769024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-223.1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1597\/13-076"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2013.794475"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.01.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1460-6984.12406"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181d60763"},{"key":"e_1_2_7_22_1","volume-title":"Denver II Training Manual","author":"Frankenburg WK","year":"1992"},{"key":"e_1_2_7_23_1","unstructured":"Menezes MLM.ADL: avalia\u00e7\u00e3o do desenvolvimento da linguagem. Rio de Janeiro 2004. (in Portuguese)"},{"issue":"11","key":"e_1_2_7_24_1","first-page":"S88","article-title":"Development outcomes of Thai children with cleft lip\/palate at 5\u2010years\u2010old","volume":"95","author":"Rongbudsri S","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1997)034<0218:DOIATW>2.3.CO;2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1044\/2016_AJSLP-16-0030"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/1982-021620151114"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.02.027"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1544114"},{"key":"e_1_2_7_30_1","first-page":"73","volume-title":"Cleft Lip and Palate: An Interdisciplinary Approach","author":"Bertier CE","year":"2007"},{"key":"e_1_2_7_31_1","first-page":"e20160146","article-title":"Speech profile of patients undergoing primary palatoplasty","volume":"29","author":"Menegueti KI","year":"2017","journal-title":"Codas"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ped4.12250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T14:56:14Z","timestamp":1693580174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/ped4.12250"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12250","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"2020-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}