{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:30:01Z","timestamp":1790389801452,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Congenital tuberculosis (TB) is a rare, potentially fatal disease. There is currently a lack of detailed clinical information available regarding this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective study investigated the clinical manifestations, treatment, and long\u2010term prognosis of congenital TB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated in Beijing Children\u2019s Hospital, Capital Medical University (Beijing, China) between 2009 and 2018. Their demographic data, maternal and family histories, symptoms and signs, treatment information, and follow\u2010up data were retrospectively collected using the hospital\u2019s electronic information system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten infants with congenital TB were enrolled. The mean gestational age was 36.6 \u00b1 2.2 weeks and mean birth weight was 2517 \u00b1 487 g. All 10 patients exhibited fever, nine patients (90%) had anemia, and six patients (60%) had extrauterine growth retardation. On chest computed tomography scans, all 10 patients presented multiple pulmonary nodules and four patients (40%) had mediastinal adenopathy. Nine out of ten (90%) completed the T\u2010spot test, and eight of them (8\/9, 89%) were positive. Anti\u2010TB treatment was initiated upon diagnostic confirmation. All patients (100%) received combined treatment with isoniazid (INH) and rifampicin (RIF). Eight of 10 patients (80%) received combined treatment with INH, RIF, and pyrazinamide. The survival rate was 100%. One patient was lost to follow\u2010up and four patients are currently continuing treatment. Three of nine patients (33%) achieved normal developmental milestones at 6 months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Early diagnosis based on maternal history, typical imaging results, and timely treatment can improve outcomes in infants with congenital TB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12266","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T13:10:33Z","timestamp":1624021833000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical characteristics and post\u2010discharge follow\u2010up analyses of 10 infants with congenital tuberculosis: A retrospective observational study"],"prefix":"10.1002","volume":"5","author":[{"given":"Juan","family":"Du","sequence":"first","affiliation":[{"name":"Neonatal Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiao","family":"Dong","sequence":"additional","affiliation":[{"name":"Neonatal Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Jia","sequence":"additional","affiliation":[{"name":"Neonatal Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neonatal Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Hei","sequence":"additional","affiliation":[{"name":"Neonatal Center Beijing Children\u2019s Hospital Capital Medical University National Center for Children\u2019s Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization(2017).Global tuberculosis report 2017.https:\/\/apps.who.int\/iris\/handle\/10665\/259366. Accessed September 1 2020."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21490"},{"key":"e_1_2_7_4_1","first-page":"14","article-title":"Expert consensus on linezolid for the treatment of tuberculosis","volume":"41","author":"Tang S","year":"2018","journal-title":"Chin J Tuberc Respir Dis"},{"key":"e_1_2_7_5_1","unstructured":"World Health Organization(2018).WHO treatment guidelines for isoniazid\u2010resistant tuberculosis: Supplement to the WHO treatment guidelines for drug\u2010resistant tuberculosis.https:\/\/apps.who.int\/iris\/handle\/10665\/260494. Accessed September 1 2020."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1152249"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.38.1.27"},{"key":"e_1_2_7_8_1","unstructured":"World Health Organization(2014).Guidance for national tuberculosis programmes on the management of tuberculosis in children 2nd ed.https:\/\/apps.who.int\/iris\/handle\/10665\/112360. Accessed September 1 2020."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301505"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.146"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.6.494"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TNMI7-0037-2016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080054"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1008049"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.1.1820253"},{"key":"e_1_2_7_16_1","first-page":"127","article-title":"Clinical and imaging features of congenital tuberculosis","volume":"43","author":"Wang X","year":"2014","journal-title":"J Med Res"},{"key":"e_1_2_7_17_1","first-page":"981","article-title":"Clinical and imaging features of congenital tuberculosis","volume":"50","author":"Wang Y","year":"2016","journal-title":"Chin J Radiol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200507040-00002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.416-417.2003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/648675"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0632-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000086955.93702.c7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2008.1217"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001114"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108789"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ped4.12266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:27:17Z","timestamp":1693423637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ped4.12266"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12266","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}