{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:44Z","timestamp":1786978304447,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Vitamin A (or retinol) has considerable antioxidative and anti\u2010inflammatory attributes and it may have protective effects on the respiratory health of patients with cystic fibrosis (CF). This issue, however, remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of the present study was to investigate the relationship between serum retinol levels (SRL) and force expiratory volume in 1 second (FEV1) in patients with CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with pancreatic insufficiency attending the CF Department of \u201cAgia Sofia\u201d Children\u2019s Hospital in Athens, Greece, aged 6 to 19 years during the 2012\u20132016 period, who could perform spirometry effectively, were included in the study. The impact of SRL on FEV1 was examined longitudinally and analyzed with generalized estimating equations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 231 patients and 851 SRL measurements were performed. In 25 (3.2%) cases the SRL were below the 5th percentile of reference distribution; none was above the 95th percentile. The analysis showed that SRL was positively correlated with the FEV1 (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this sample of children and adolescents with CF, vitamin A deficiency was rare. Our results suggest a positive relationship between SRL and FEV1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.12270","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T09:10:33Z","timestamp":1624007433000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of vitamin A status with lung function in children and adolescents with cystic fibrosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Ioanna","family":"Loukou","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Department \u201cAgia Sofia\u201d Children\u2019s Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moustaki","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department \u201cAgia Sofia\u201d Children\u2019s Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Sardeli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Respiratory Unit Third Department of Pediatrics \u201cAttikon\u201d University Hospital National and Kapodistrian University of Athens School of Medicine  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Plyta","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department \u201cAgia Sofia\u201d Children\u2019s Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Katsagoni","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department \u201cAgia Sofia\u201d Children\u2019s Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Douros","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Respiratory Unit Third Department of Pediatrics \u201cAttikon\u201d University Hospital National and Kapodistrian University of Athens School of Medicine  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02002713"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.2.358"},{"key":"e_1_2_7_4_1","first-page":"CD006751","article-title":"Vitamin A and beta (\u03b2)\u2010carotene supplementation for cystic fibrosis","volume":"8","author":"Vries JJ","year":"2018","journal-title":"Cochrane Database of Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.04.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4845"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.4.4478"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.10.1661"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.7.1285"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2005.11.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31828b1d90"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20041"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31804069e5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.11.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.01.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.4.635"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24460"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15169"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001676"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"e_1_2_7_21_1","unstructured":"U.S. Centers for Disease Control and Prevention.National Center for Environmental Health Second national report on biochemical indicators of diet and nutrition in the US Population (2012).https:\/\/www.cdc.gov\/nutritionreport\/pdf\/Nutrition_Book_complete508_final.pdf. 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