{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:14Z","timestamp":1777494734092,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770517"],"award-info":[{"award-number":["81770517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Cadherin\u201011 (CDH11), a cell\u2010to\u2010cell adhesion molecule, is implicated in the fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease featuring cholestasis and progressive liver fibrosis in children. Cholestatic liver fibrosis may progress to liver cirrhosis and lacks effective therapeutic strategies. Currently, the role of CDH11 in cholestatic liver fibrosis remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the functions of CDH11 in cholestatic liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of <jats:italic>CDH11<\/jats:italic> in BA livers was evaluated by database analysis and immunostaining. Seven BA liver samples were used for immunostaining. The wild type (Wt) and <jats:italic>CDH11<\/jats:italic> knockout (<jats:italic>CDH11<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic>) mice were subjected to bile duct ligation (BDL) to induce cholestatic liver fibrosis. The serum biochemical analysis, liver histology, and western blotting were used to assess the extent of liver injury and fibrosis as well as activation of transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2)\/Smad pathway. The effect of CDH11 on the activation of hepatic stellate cell line LX\u20102 cells was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of public RNA\u2010seq datasets showed that <jats:italic>CDH11<\/jats:italic> expression levels were significantly increased in livers of BA, and CDH11 was correlated with liver fibrosis in BA. BDL\u2010induced liver injury and liver fibrosis were attenuated in <jats:italic>CDH11<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> mice compared to Wt mice. The protein expression levels of phosphorylated Smad2\/3 were decreased in livers of <jats:italic>CDH11<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> BDL mice compared to Wt BDL mice. <jats:italic>CDH11<\/jats:italic> knockdown inhibited the activation of LX\u20102 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>CDH11 plays an important role in cholestatic liver fibrosis and may represent a potential therapeutic target for cholestatic liver disease, such as BA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12317","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T09:15:48Z","timestamp":1647940548000},"page":"100-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of cadherin\u201011 contributes to cholestatic liver fibrosis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-7653","authenticated-orcid":false,"given":"Bo","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Xin Hua Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xin Hua Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xin Hua Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xin Hua Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongtao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xin Hua Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38275"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019437108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137306"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201013\u20100108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.52720"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S306073"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010186098"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.09.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz147"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218971"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.11.153"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.05.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30698"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2020.12.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00460"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1615"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.05.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.115"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27045"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3791\/52438"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.099"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010020\u201001534\u20106"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.033"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.07.008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.01.003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14508"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.29"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400062111"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153294"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0055"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30662"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3823"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131545"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15175"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9081014"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(03)00432\u2010x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3434"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415627681"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ped4.12317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:15:45Z","timestamp":1692645345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/ped4.12317"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12317","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"value":"2574-2272","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]},"assertion":[{"value":"2021-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}