{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:50:34Z","timestamp":1747151434914,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Body fluid dynamics and renal maturation status vary during the neonatal period. We hypothesized that differences in peak and trough gentamicin concentrations could be expected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To predict the peak and trough gentamicin concentrations in critically ill neonates and to predict the changes in the predicted peak plasma concentrations of gentamicin following fat\u2010free mass dosing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Critically ill neonates that received gentamicin and have gentamicin concentration measured were recruited. Fat mass was estimated using skinfold thicknesses. Changes in the peak plasma concentrations (C<jats:sub>max<\/jats:sub>) using whole\u2010body weight (estimated using the current dosing regimen) and predicted concentrations following the fat\u2010free mass\u2010based dosing were the outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine critically ill neonates were recruited. Sub\u2010therapeutic C<jats:sub>max<\/jats:sub> was estimated using the current dosing regimen in 32.6%, and 22.5% neonates following the first and second doses of gentamicin. Preterm neonates had significantly higher fat mass compared to term neonates. All except one had C<jats:sub>max<\/jats:sub> above 12\u202f\u03bcg\/ml after the first dose and all had after the second gentamicin dose following the predicted fat\u2010free mass\u2010based gentamicin dosing. The recommended doses are as follows: extreme preterm: 7.95\u202fmg\/kg every 48 h; very preterm: 7.30\u202fmg\/kg every 36\u201348 h; late preterm: 5.90\u202fmg\/kg every 36\u201348 h; and term neonates at 5.10\u202fmg\/kg every 24 h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Fat\u2010free mass dosing may be considered for obtaining optimal therapeutic effects in the neonatal population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.12386","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:08:50Z","timestamp":1686208130000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is fat\u2010free mass\u2010based gentamicin dosing regimen preferable than whole\u2010body weight in neonates?"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-6503","authenticated-orcid":false,"given":"Kannan","family":"Sridharan","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics College of Medicine and Medical Sciences Arabian Gulf University  Manama Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna","family":"Al Jufairi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Salmaniya Medical Complex Ministry of Health  Manama Kingdom of Bahrain"},{"name":"Department of Pediatrics College of Medicine and Medical Sciences Arabian Gulf University  Manama Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Al Ansari","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Salmaniya Medical Complex Ministry of Health  Manama Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulwa","family":"Alsadah","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Sciences Arabian Gulf University  Manama Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howra","family":"Wasel","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Sciences Arabian Gulf University  Manama Kingdom of Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr1858w"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.10.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518003355"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13829"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12072"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14735"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005237\u2010199406000\u201000006"},{"key":"e_1_2_6_9_1","unstructured":"European Medicines Agency.Discussion paper on the impact of renal immaturity when investigating medicinal products intended for paediatric use. Accessed December 16 2004.https:\/\/www.ema.europa.eu\/en\/documents\/scientific\u2010guideline\/discussion\u2010paper\u2010impact\u2010renal\u2010immaturity\u2010when\u2010investigating\u2010medicinal\u2010products\u2010intended\u2010paediatric_en.pdf"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010017\u20100844\u20106"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5935\/MedicalExpress.2015.05.01"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20109\u201021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.045"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.6.887"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2020.01.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102710.1995.tb00659.x"},{"key":"e_1_2_6_17_1","first-page":"231","article-title":"Effect of water deprivation and rehydration on gentamicin disposition in the rat","volume":"218","author":"Lecompte J","year":"1981","journal-title":"J Pharmacol Exp Ther."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2020.105163"},{"key":"e_1_2_6_19_1","unstructured":"Micromedex NeoFax essentials2014. Accessed November 22 2020.http:\/\/ypeda.com\/attachments\/fil\/Micormedex%20NeoFax%20Essentials%202014%20(1).pdf"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200221666200512111131"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.977372"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010019\u20101676\u20103"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-021-00708-x"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T03:05:29Z","timestamp":1692500729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/ped4.12386"],"URL":"https:\/\/doi.org\/10.1002\/ped4.12386","archive":["Portico"],"relation":{},"ISSN":["2574-2272","2574-2272"],"issn-type":[{"type":"print","value":"2574-2272"},{"type":"electronic","value":"2574-2272"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}