{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:24:19Z","timestamp":1784604259128,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010258","name":"Marfan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Myopia of Marfan syndrome (MFS) may be ascribed to crystalline lens subluxation, abnormal corneal curvature, and increased globe axial length.\u00a0Few studies have reported these measures in MFS children who did or did not have ectopia lentis (EL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To measure eye findings longitudinally in MFS children with and without EL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, comparative case study was conducted on 24 MFS children (48 eyes). EL necessitated lensectomy and intraocular lens implantation surgery in 16\/24 children (mean age 5.6 \u00b1 2.8 years). The remaining 8\/24 MFS children (mean age 11.2 \u00b1 4.2 years) had no EL and were phakic. Follow\u2010up was a mean of 3.1 \u00b1 0.5 years. At follow\u2010up visits, visual acuity, tonometry, refractive error, central corneal thickness (CCT), biomicroscopic examination, axial length, anterior chamber depth, endothelial cell density (ECD), and corneal curvature were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the initial visit, before EL surgery, MFS children with EL had greater myopia (<jats:italic>P<\/jats:italic> &lt; 0.01), corneal cylinder (<jats:italic>P<\/jats:italic> = 0.04), and CCT (<jats:italic>P<\/jats:italic> = 0.01) compared to children with no EL. Over the follow\u2010up interval, EL children had a progressive increase in CCT (<jats:italic>P<\/jats:italic> = 0.02) and a reduction in ECD (<jats:italic>P<\/jats:italic> = 0.02). EL children also showed: progressive flattening of corneal curvature (<jats:italic>P<\/jats:italic> = 0.01); reduction of corneal cylinder (<jats:italic>P<\/jats:italic> = 0.02); and increase in axial length (<jats:italic>P<\/jats:italic> &lt; 0.01). MFS children with no EL exhibited a smaller increase in CCT (<jats:italic>P<\/jats:italic> &lt; 0.01) and a milder flattening of corneal curvature (<jats:italic>P<\/jats:italic> &lt; 0.01). The no EL children showed no change in ECD (<jats:italic>P<\/jats:italic> = 0.09), corneal cylinder (<jats:italic>P<\/jats:italic> = 0.80), or axial length (<jats:italic>P<\/jats:italic> = 0.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>MFS children who have EL exhibit differences in corneal structure and axial length when compared to MFS children with no EL. Children with EL have thicker CCT, more corneal cylinder, lower ECD, and longer axial lengths compared to children with no EL. The differences imply that the fibrillin defect of MFS is more severe in children with EL. The ocular defect is manifested chiefly as zonular hyperextension but has effects also on corneal and scleral integrity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ped4.70011","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:15:56Z","timestamp":1747653356000},"page":"160-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Corneal characteristics in children with Marfan syndrome with or without ectopia lentis"],"prefix":"10.1002","volume":"9","author":[{"given":"Marisa","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences St. Louis Children's Hospital at Washington University Medical Center St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-1576","authenticated-orcid":false,"given":"Lawrence","family":"Tychsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences St. Louis Children's Hospital at Washington University Medical Center St. Louis Missouri USA"},{"name":"Department of Pediatrics St. Louis Children's Hospital at Washington University Medical Center St. Louis Missouri USA"},{"name":"Department of Neuroscience St. Louis Children's Hospital at Washington University Medical Center St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/26330040211055738"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100902"},{"key":"e_1_2_7_5_1","first-page":"684","article-title":"The eye in the Marfan syndrome","volume":"79","author":"Maumenee IH","year":"1981","journal-title":"Trans Am Ophthalmol Soc."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20103768.2010.01996.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118761333"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.12.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.01.063"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2022.03.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.02.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.13389\/j.cnki.rao.2017.0262"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1436834"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108001"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T15:06:17Z","timestamp":1750259177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ped4.70011"],"URL":"https:\/\/doi.org\/10.1002\/ped4.70011","archive":["Portico"],"relation":{},"ISSN":["2096-3726","2574-2272"],"issn-type":[{"value":"2096-3726","type":"print"},{"value":"2574-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2024-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}