{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:23:49Z","timestamp":1766150629426,"version":"3.48.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Hypertensive disorders in pregnancy (HDPs) are common and increase the risk of maternal and fetal morbidity and mortality. HDPs may impact fetal growth; however, sex\u2010specific effects have been understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether sex\u2010specific differences exist in the association between HDPs and birthweight and placental weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A birth cohort based in Detroit, Michigan, was utilized (\n                      <jats:italic>n<\/jats:italic>\n                      = 1258). HDPs and birthweight were abstracted from medical records; placental weight was obtained from placental pathology reports. Linear regression was used to model sex\u2010specific associations, after multiple imputation, confounder adjustment, and inverse probability weighting to account for selection bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary analysis included all pregnancies (\n                      <jats:italic>n<\/jats:italic>\n                      = 853), while the secondary analysis included those sent for placental pathology, reflective of complicated pregnancies (\n                      <jats:italic>n<\/jats:italic>\n                      = 165). In the primary analysis subset, males of mothers with gestational hypertension had birthweight Z\u2010scores that were on average 0.90 standard deviations higher, but this association was not found among females (interaction\n                      <jats:italic>P<\/jats:italic>\n                      = 0.019; male \u03b2 [95% confidence interval {CI}]: 0.90 [0.28, 1.52]; female \u03b2 [95% CI]: \u22120.12 [\u22120.65, 0.41]). However, in the subset of complicated pregnancies, female mothers with gestational hypertension also had reduced birthweight (interaction\n                      <jats:italic>P<\/jats:italic>\n                      = 0.013; male \u03b2 [95% CI]: 1.50 [0.15, 2.86]; female \u03b2 [95% CI]: \u22121.14 [\u22122.13, \u22120.16]). For fetoplacental weight ratio, any HDP was associated with a lower ratio among females only (interaction\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028; male \u03b2 [95% CI]: \u22120.04 [\u22120.71, 0.64]; female \u03b2 [95% CI]: \u22120.95 [\u22121.57, \u22120.33]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Male fetuses may prioritize growth, whereas females may prioritize placental development when exposed to HDPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70015","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T17:45:25Z","timestamp":1752255925000},"page":"372-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010specific associations between hypertensive disorders in pregnancy and fetal and placental weight"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-389X","authenticated-orcid":false,"given":"Alexandra R.","family":"Sitarik","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Epidemiology and Biostatistics College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesa","family":"Wegienka","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Obstetrics Gynecology and Reproductive Biology College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Obstetrics Gynecology and Reproductive Biology College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raminder","family":"Khangura","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology Henry Ford Health  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-524X","authenticated-orcid":false,"given":"Jennifer K.","family":"Straughen","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Obstetrics Gynecology and Reproductive Biology College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E.","family":"Cassidy\u2010Bushrow","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Pediatrics and Human Development College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7117a1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010021\u201003809\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018155"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.05.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371\u2010018\u20100150\u20102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105735"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15143104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286287"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126386"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20995"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.039"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21612"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u20103\u20106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000010163"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v059.i12"},{"key":"e_1_2_8_18_1","unstructured":"BarrettM.ggdag: analyze and create elegant directed acyclic graphs.2024."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac126"},{"key":"e_1_2_8_20_1","first-page":"283","article-title":"Racial\/ethnic differences in pregnancy\u2010related hypertensive disease in nulliparous women","volume":"24","author":"Ghosh G","year":"2014","journal-title":"Ethn Dis."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.07.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000135174.63482.43"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16\u20102607"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174422000204"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174415001348"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296853"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6839416"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20109668.136182"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000317"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14176"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010016\u20100108\u20104"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100632"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.12.008"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.010"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.70015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:22:05Z","timestamp":1766150525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.70015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ped4.70015"],"URL":"https:\/\/doi.org\/10.1002\/ped4.70015","archive":["Portico"],"relation":{},"ISSN":["2096-3726","2574-2272"],"issn-type":[{"type":"print","value":"2096-3726"},{"type":"electronic","value":"2574-2272"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}