{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:23:47Z","timestamp":1766150627801,"version":"3.48.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, particularly after the coronavirus disease 2019 pandemic. As children with IBD are at higher risk of infection, adherence to vaccination schedules is essential. However, data on the incidence of IBD and vaccination coverage in Italian children remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the incidence of IBD in children aged 0\u201314 years in the Apulia region of Italy (2009\u20132023) and to evaluate their vaccination coverage for both mandatory and recommended vaccines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective population\u2010based study was conducted using hospital discharge records and a user fee exemption registry to identify incident IBD cases. Vaccination history was obtained from the regional immunization system. Age\u2010standardized incidence rates (SIRs) were calculated. Vaccination coverage was assessed based on the receipt of all age\u2010appropriate vaccines according to regional immunization schedules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2009 and 2023, 1044 incident pediatric IBD cases were identified, with an average annual SIR of 12.7\/100\u00a0000. A significant increase in incidence occurred after 2020 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), peaking in the 10\u201314 age group. Among the 259 patients assessed for vaccination coverage, the rates were high for hexavalent (100.0%) and pneumococcal vaccines (99.2%), moderate for rotavirus (82.5%) and meningococcal vaccines (79.9%), and lower for human papillomavirus (66.3% in females and 52.1% in males) and diphtheria\u2010tetanus\u2010acellular pertussis and inactivated polio vaccines (dTap\u2010IPV) booster (30.2%). Influenza coverage in 2023\/24 was 18.9%. Children with complex chronic conditions had lower uptake of measles, mumps, and rubella and dTap\u2010IPV boosters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The incidence of pediatric IBD is increasing in Apulia, whereas vaccination coverage remains below optimal levels. Targeted strategies are needed to enhance immunization in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70023","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:06:24Z","timestamp":1758189984000},"page":"383-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 15\u2010year population\u2010based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-5385","authenticated-orcid":false,"given":"Francesca","family":"Fortunato","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences Hygiene Unit University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Campanozzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Pediatrics Unit University of Foggia  Foggia Italy"},{"name":"Department of Pediatrics Policlinico Foggia Hospital  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Di Toma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Policlinico Foggia Hospital  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marinari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Policlinico Foggia Hospital  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Hygiene Unit University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010036584"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1982"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.282"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003511"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32448\u20100"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010024\u201004640\u20109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i25.2741"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.12.018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003740"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otad062"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.05.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otaa056"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010021\u201006976\u2010x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010022\u201001953\u2010w"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01108.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050487"},{"key":"e_1_2_6_20_1","first-page":"1534","article-title":"Management of varicella infection during the course of inflammatory bowel disease","volume":"92","author":"Mouzas IA","year":"1997","journal-title":"Am J Gastroenterol."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2007.01582.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.406"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.034"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794\u00d719849754"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824d1438"},{"key":"e_1_2_6_26_1","unstructured":"Recommendations and vaccination offers for risk conditions 2023\u20132025. National Vaccination Prevention Plan Emilia Romagna Region (in Italy). Accessed February 14 2025.https:\/\/salute.regione.emilia\u2010romagna.it\/sanita\u2010pubblica\/vaccinazioni\/vaccinazioni\u2010per\u2010target\u2010diversi\/vaccinazioni\u2010per\u2010specifiche\u2010condizioni\u2010di\u2010rischio"},{"key":"e_1_2_6_27_1","unstructured":"National Vaccination Prevention Plan 2023\u20132025. State\u2010Regions Conference August 2 2023. Official Gazette General Series No. 194 August 21 2023 (in Italy). Accessed February 14 2025.https:\/\/www.trovanorme.salute.gov.it\/norme\/dettaglioAtto?id=95963&completo=true"},{"key":"e_1_2_6_28_1","unstructured":"Resolution of the Regional Council No. 1589 October 5 2021. Approval of the new Life\u2010course Vaccination Schedule of the Apulia Region \u2013 2021 edition. Official Bulletin of the Apulia Region \u2013 No. 135 of October 29 2021 (in Italy). Accessed February 16 2025.https:\/\/www.sanita.puglia.it\/documents\/20182\/285275922\/DGR+1589_2021+Nuovo+calendario+vaccinale+ed.2021.pdf\/186500a3\u2010134e\u20104dae\u20109d5c\u2010c6e139280bcd"},{"key":"e_1_2_6_29_1","unstructured":"Resolution of the Regional Council No. 1365 October 10 2022. Regional operational program for Herpes Zoster vaccination in accordance with the National Immunization Plan 2017\u20132019. Official Bulletin of the Apulia Region \u2013 No. 115 of October 25 2022 (in Italy). Accessed March 1 2025.https:\/\/www.sanita.puglia.it\/documents\/20182\/285275922\/DGR+1365_2022+Vaccinazione+anti+Herpes+Zoster_Approvazione+documento+di+indirizzo.pdf\/00471d59\u20108d2f\u20104210\u2010a94f\u20101cae3cde53c8"},{"key":"e_1_2_6_30_1","unstructured":"Resolution of the Regional Council No. 958 May 20 2014. Regional Vaccination Commission. Amendment to the 2012 Life\u2010course Vaccination Schedule \u2013 Resolution 241\/2013. Approval of the new 2014 Life\u2010course Vaccination Schedule \u2013 Apulia Region (in Italy). Accessed March 3 2025.https:\/\/www.vaccinarsinpuglia.org\/assets\/uploads\/files\/22\/Modifica_calendario_vaccinale_regionale_DGR_958_20_maggio_2014.pdf"},{"key":"e_1_2_6_31_1","unstructured":"Life\u2010course Vaccination Schedule 2018 \u2013 Apulia Region (in Italy). Accessed March 5 2025.https:\/\/www.sanita.puglia.it\/documents\/20182\/26673928\/Calendario+vaccinale+per+la+vita+2018\/f36429b9\u20105f76\u201044c2\u2010b495\u2010d5b9228959ef?version=1.0&"},{"key":"e_1_2_6_32_1","unstructured":"OER Puglia.Relazione sullo stato di salute della popolazione pugliese. Anni 2006\u20132011. Capitolo 5. Malattie infettive e vaccinazioni. Available from:https:\/\/www.vaccinarsinpuglia.org\/assets\/uploads\/files\/23\/Stato_di_Salute_Popolazione_Pugliese_Anni_2006\u20102011.pdf"},{"key":"e_1_2_6_33_1","unstructured":"Regional Law December 29 2017 No. 67. \u201cProvisions for the preparation of the 2018 budget and the 2018\u20132020 multi\u2010year budget of the Apulia Region (regional stability law 2018)\u201d. Official Bulletin of the Apulia Region \u2013 No. 149 of December 30 2017 (in Italy). Accessed March 15 2025.https:\/\/trasparenza.regione.puglia.it\/sites\/default\/files\/norma\/LR_67_2017.pdf"},{"key":"e_1_2_6_34_1","unstructured":"Official Bulletin of the Apulia Region \u2013 No. 150 of December 30 2016 (in Italy). Accessed March 18 2025.https:\/\/www.vaccinarsinpuglia.org\/assets\/uploads\/files\/191\/legge\u2010regionale\u2010n.40\u2010del\u20102016\u2010art.\u201052.pdf"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010024\u201001617\u2010w"},{"key":"e_1_2_6_36_1","unstructured":"Revision of the European Standard Population \u2010 Report of Eurostat's task force \u2010 2013 edition. Accessed March 18 2025.https:\/\/ec.europa.eu\/eurostat\/web\/products\u2010manuals\u2010and\u2010guidelines\/\u2010\/ks\u2010ra\u201013\u2010028"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.08.016"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002379"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820915043"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14070"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.043"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2024.1607440"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.09.120"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243774"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjae082"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010019\u20100702\u20103"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjad212.1252"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002885"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122469"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i42.7644"},{"key":"e_1_2_6_51_1","unstructured":"Italian Ministry of Health Vaccination Report. Accessed March 18 2025.https:\/\/www.salute.gov.it\/new\/it\/tema\/covid\u201019\/report\u2010vaccini\u2010anti\u2010covid\u201019\/"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.11.019"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13187\u2010024\u201002516\u20108"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.02.009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010024\u201006151\u2010x"}],"container-title":["Pediatric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ped4.70023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:22:01Z","timestamp":1766150521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ped4.70023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ped4.70023"],"URL":"https:\/\/doi.org\/10.1002\/ped4.70023","archive":["Portico"],"relation":{},"ISSN":["2096-3726","2574-2272"],"issn-type":[{"type":"print","value":"2096-3726"},{"type":"electronic","value":"2574-2272"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"assertion":[{"value":"2025-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}