{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:01:34Z","timestamp":1774882894146,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Infectious mononucleosis (IM) and Kawasaki disease (KD) can present with overlapping clinical features, occasionally complicating the differential diagnosis. Given the significant differences in their management, accurate distinction is critical. It is exceptionally rare for a single patient to simultaneously suffer from both IM and KD in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report two cases of children over five years of age who initially presented with clinical manifestations suggestive of IM and serological evidence consistent with primary Epstein\u2010Barr virus (EBV) infection, supporting an initial diagnosis of IM. Subsequently, both patients developed clinical features meeting the diagnostic criteria for KD. The final diagnosis was co\u2010occurrence of IM and KD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We describe two cases of concurrent IM and KD, offering further insight into a possible association between primary EBV infection and KD. Clinicians should be mindful of the potential co\u2010occurrence of these disorders, strive to avoid conflicts in treatment strategies, and take proactive measures to prevent complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70026","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:40:08Z","timestamp":1761896408000},"page":"410-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Infectious mononucleosis complicated with Kawasaki disease: Two case reports and literature review"],"prefix":"10.1002","volume":"9","author":[{"given":"Mengjia","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Pathogen Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases Laboratory of Infection and Virology Beijing Pediatric Research Institute Beijing Children\u2019 s Hospital Capital Medical University National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Center for Children's Health National Center for Children's Infectious and Allergic Diseases Surveillance Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Center for Children's Health National Center for Children's Infectious and Allergic Diseases Surveillance Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Dilmurat","sequence":"additional","affiliation":[{"name":"Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases Laboratory of Infection and Virology Beijing Pediatric Research Institute Beijing Children\u2019 s Hospital Capital Medical University National Center for Children's Health  Beijing China"},{"name":"Research Unit of Critical infection in Children Chinese Academy of Medical Sciences 2019RU016  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-741X","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Center for Children's Health National Center for Children's Infectious and Allergic Diseases Surveillance Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education Beijing Children's Hospital Capital Medical University  Beijing China"},{"name":"Research Unit of Critical infection in Children Chinese Academy of Medical Sciences 2019RU016  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-9338","authenticated-orcid":false,"given":"Zhengde","family":"Xie","sequence":"additional","affiliation":[{"name":"Beijing Research Center for Respiratory Infectious Diseases Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases Laboratory of Infection and Virology Beijing Pediatric Research Institute Beijing Children\u2019 s Hospital Capital Medical University National Center for Children's Health  Beijing China"},{"name":"Research Unit of Critical infection in Children Chinese Academy of Medical Sciences 2019RU016  Beijing 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