{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:06:52Z","timestamp":1782281212916,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Infantile dilated cardiomyopathy (DCM) associated with left bundle branch block (LBBB) is a rare but life\u2010threatening condition, especially when severe heart failure is present. Identifying effective solutions to improve the prognosis is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the short\u2010term clinical outcomes and cardiac functional changes in infants with LBBB\u2010associated DCM treated with a combined approach of electrical and mechanical cardiac resynchronization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of five infants who underwent epicardial cardiac resynchronization therapy (CRT) combined with pulmonary artery banding between 2023 and 2024. The primary endpoint was improvement in clinical functional class and cardiac function, assessed by left ventricular ejection fraction (LVEF) and N\u2010terminal pro\u2010B\u2010type natriuretic peptide levels. Secondary endpoints included indicators of cardiac reverse remodeling, evaluated by LV end\u2010diastolic dimension (LVEDd), its z\u2010score, cardiac resynchronization, and QRS duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The five enrolled infants had a median age of 6 months (range, 3\u201312 months). All received guideline\u2010directed medical therapy and were followed for a median of 11 months (range, 6\u201324 months). All patients achieved normalization of functional class. The median LVEF increased from 26% to 65%, with improvements observed within 1 month. The median LVEDd decreased from 46 to 28 mm, and the corresponding z\u2010score decreased from 11.2 (range, 7.6\u201313.2) to 0.7 (range, \u20131.1 to 2.3). The median QRS duration narrowed from 138 to 115 ms. Mechanical dyssynchrony was virtually resolved in all patients by the last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The combined resynchronization strategy appears to be highly effective for treating infants with LBBB\u2010associated DCM. Further studies are needed to differentiate the specific roles of electrical and mechanical synchronization in improving outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70035","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:05:14Z","timestamp":1768489514000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac resynchronization therapy and pulmonary artery banding in advanced heart failure infants with left ventricular dilated cardiomyopathy and left bundle branch block"],"prefix":"10.1002","volume":"10","author":[{"given":"Min","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiac Center National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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