{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:19:01Z","timestamp":1783505941925,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The prognosis of pediatric refractory\/relapsed non\u2010Hodgkin lymphoma (R\/R NHL) remains poor, with limited evidence guiding optimal treatment. Haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT) is a promising strategy for this high\u2010risk population. However, the optimal conditioning regimen and long\u2010term outcomes of haplo\u2010HSCT have not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the long\u2010term efficacy and safety of antithymocyte globulin (ATG)\u2010based myeloablative haplo\u2010HSCT in pediatric patients with R\/R NHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pediatric patients with R\/R NHL who underwent ATG\u2010based myeloablative haplo\u2010HSCT at Beijing Children's Hospital between March 2015 and December 2021 were retrospectively enrolled. Overall survival (OS) and progression\u2010free survival (PFS) were estimated using the Kaplan\u2013Meier method and compared using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 29 pediatric R\/R NHL patients were enrolled, including 21 with lymphoblastic lymphoma and 8 with mature T\u2010cell and natural killer\u2013cell lymphoma. The 5\u2010year OS, PFS, cumulative incidence of relapse, and non\u2010relapse mortality were 79.3%, 72.4%, 10.0%, and 17.0%, respectively. At a median follow\u2010up of 5.5 years, the cumulative incidences of Grade III\u2013IV acute graft\u2010versus\u2010host disease (GVHD) and chronic GVHD were 13.8% (4\/29) and 44.8% (13\/29; predominantly mild), respectively. Thrombotic microangiopathy (TMA) developed in 12 patients and was associated with significantly inferior prognosis (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>ATG\u2010based myeloablative haplo\u2010HSCT is a safe and effective treatment for pediatric R\/R NHL, offering a viable alternative for patients lacking matched donors or requiring urgent intervention. Early detection and timely treatment of TMA may reduce mortality and improve survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70070","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:51:39Z","timestamp":1783504299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin\u2013based myeloablative conditioning in pediatric refractory or relapsed non\u2010Hodgkin lymphoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-1048","authenticated-orcid":false,"given":"Chenguang","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-7206","authenticated-orcid":false,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"},{"name":"Department of Stem Cell Transplantation Baoding Children's Hospital Beijing Children's Hospital Capital Medical University National Center for Children's Health  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"He","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Baoding Children's Hospital Beijing Children's Hospital Capital Medical University National Center for Children's Health  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"},{"name":"Department of Stem Cell Transplantation Baoding Children's Hospital Beijing Children's Hospital Capital Medical University National Center for Children's Health  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children Ministry of Education; Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing China"},{"name":"Department of Stem Cell Transplantation Baoding Children's Hospital Beijing Children's Hospital Capital Medical University National Center for Children's Health  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Hematology Center Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital 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