{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:40:25Z","timestamp":1792600825287,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Oscillometry \u2014 a tidal\u2010breathing test with potential advantages over spirometry \u2014 is not well studied prior to hematopoietic stem cell transplantation (HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether patients awaiting HSCT have abnormal baseline oscillometry compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TRANSPIRE study (NCT04098445) is a National Institutes of Health\u2010sponsored, multicenter, prospective observational cohort of pediatric lung injury after HSCT. We performed tidal\u2010breathing oscillometry at baseline and during follow\u2010up in 63 children prior to HSCT across five pediatric centers and compared results to 80 control subjects. Measurements were made at various frequencies following the European Respiratory Society 2020 guidelines and included resistance (R5, R19, and R5\u2013R19), reactance (X5 and X11), resonant frequency (Fres), and area under the reactance curve (AX). Linear regression compared TRANSPIRE baseline values to controls; mixed\u2010effects models assessed differences between TRANSPIRE subjects, controls, and published predicted values up to two years post\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All mean oscillometric parameters were normal at baseline, according to normal reference values of Ducharme. However, mean lung function in TRANSPIRE subjects was significantly different from controls, with higher respiratory system resistance (height\u2010adjusted R5\u2212R19,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and greater respiratory system stiffness and heterogeneity, with more negative height\u2010adjusted X5 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and height\u2010adjusted X11 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), greater height\u2010adjusted AX (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and greater height\u2010adjusted Fres (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). No significant changes were noted over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In a multicenter pediatric HSCT cohort, baseline oscillometry differed significantly from controls, showing heterogeneous increases in small\u2010airway resistance and respiratory\u2010system stiffness that may elevate risk for pulmonary complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70072","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:36:25Z","timestamp":1782747385000},"page":"395-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory profile of pediatric patients undergoing hematopoietic stem cell transplantation studied by oscillometry \u2013 A TRANSPIRE cohort"],"prefix":"10.1002","volume":"10","author":[{"given":"Maureen B.","family":"Parenti","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia, Philadelphia  Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania, Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-0010","authenticated-orcid":false,"given":"Julian","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia, Philadelphia  Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania, Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia, Philadelphia  Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania, Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Boas","sequence":"additional","affiliation":[{"name":"Section of Pediatric Pulmonology Dartmouth Health Children's, Lebanon  New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania, Philadelphia  Pennsylvania USA"},{"name":"Division of Oncology Children's Hospital of Philadelphia, Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Towe","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Cincinnati Children's Medical Center, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Koo","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Medical Center, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasiani","family":"Myers","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Medical Center, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Lane","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Medical Center, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gaffin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Boston Children's Hospital, Boston  Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Boston Children's Hospital, Boston  Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Boston Children's Dana Farber\/Boston Children's Cancer and Blood Disorders Center, Boston  Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Urrego","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine Benioff Children's Hospitals, Oakland  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Salinas","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant Benioff Children's Hospitals, Oakland  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Abts","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Medicine Seattle Children's Hospital, Seattle  Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Scott","family":"Baker","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center, Seattle  Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Silva\u2010Carmona","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine Texas Children's Hospital, Houston  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Doherty","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Texas Children's Cancer and Hematology Centers, Houston  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplantation and Cellular Therapy Masonic Children's Hospital, Minneapolis  Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M.","family":"Davies","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Medical Center, Cincinnati  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel B.","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Masonic Children's Hospital, Minneapolis  Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4442"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.02.506"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010020\u201000857\u20109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2020.100652"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201906\u2010433ST"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202309\u2010771OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.06.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.03.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202001\u2010006OT"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101843.2012.02141.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24897"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10\u20102133"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12263_4"},{"key":"e_1_2_7_15_1","unstructured":"National Heart Lung and Blood Institute.Guidelines for the Diagnosis and Management of Asthma 2007 (EPR\u20103). 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