{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:17:53Z","timestamp":1787973473346,"version":"build-2784847793"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Atopic dermatitis (AD) and attention\u2010deficit\/hyperactivity disorder (ADHD) frequently co\u2010occur in children and adolescents, increasing the disease burden and clinical complexity. Accumulating evidence suggests that children with AD have a higher risk of incident ADHD, a risk that is particularly pronounced in those with early\u2010onset, severe AD, or significant sleep disturbances.\u00a0The underlying mechanisms are\u00a0hypothesized to involve the dysregulation of the\u00a0\u201cinflammation\u2013itching\u2013neurobehavioral\u201d axis.\u00a0This narrative review\u00a0synthesizes current evidence regarding the epidemiology, potential mechanisms, and clinical management of this comorbidity. We propose that proactive screening and aggressive control of skin inflammation and pruritus are key to disrupting this vicious cycle.<\/jats:p>","DOI":"10.1002\/ped4.70083","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:59:51Z","timestamp":1787972391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atopic dermatitis and attention\u2010deficit\/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management"],"prefix":"10.1002","author":[{"given":"Qingyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing 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