{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:56:37Z","timestamp":1790668597542,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Investigation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Relapsed\/refractory acute lymphoblastic leukemia (R\/R ALL) remains a major challenge in pediatric hematologic malignancies, with poor outcomes following standard salvage therapy. Real\u2010world data regarding the use of bortezomib\u2010based regimens in Chinese children are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of bortezomib\u2010based chemotherapy in Chinese pediatric patients with R\/R ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 12 pediatric patients with R\/R ALL who received bortezomib\u2010based chemotherapy at our center between January 2019 and January 2026. Clinical characteristics, responses, survival, and adverse events were evaluated. Complete remission (CR), CR with incomplete recovery (CRi), persistent disease (PD), and minimal residual disease (MRD) were assessed per standard criteria. Survival probabilities were estimated using the Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients had B\u2010cell ALL (B\u2010ALL) and three had T\u2010cell ALL (T\u2010ALL). Among those with B\u2010ALL, the CR\/CRi rate was 88.9% (8\/9), and 62.5% (5\/8) of responders bridged to hematopoietic stem cell transplantation (HSCT). Notably, five of eight responders with B\u2010ALL achieved MRD &lt;0.01%, including all three refractory patients. In contrast, none of the three patients with T\u2010ALL achieved remission; all experienced PD, with a median survival of 3 months. The 3\u2010year overall survival and event\u2010free survival rates for the entire cohort were 48.6% (95% confidence interval [CI], 19.2%\u201373.0%) and 36.4% (95% CI, 5.8%\u201369.8%), respectively. Treatment\u2010related toxicities were manageable, with the most common being hematologic suppression and infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Bortezomib\u2010based chemotherapy showed promising salvage activity in pediatric patients with R\/R B\u2010ALL, enabling remission and HSCT bridging. However, its activity against T\u2010ALL appears limited in this small cohort, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ped4.70088","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:20:57Z","timestamp":1790666457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bortezomib\u2010based chemotherapy in Chinese pediatric patients with relapsed\/refractory acute lymphoblastic leukemia: A single\u2010center retrospective study"],"prefix":"10.1002","author":[{"given":"Xingyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sun Yat\u00adsen Memorial Hospital Sun Yat\u00adsen University  Guangzhou Guangdong China"},{"name":"Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat\u2010sen University  Guangzhou Guangdong 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