{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:36:05Z","timestamp":1792532165305,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["4spepublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Polymer Engineering &amp;amp; Sci"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    In this work, the preparation and characterization of a novel multifunctional collagen\u2013chitosan material containing silver nanoparticles and nonsteroid anti\u2010inflammatory drug ibuprofen is described. As a starting material, the commercially available collagen\u2013chitosan scaffold was used. Drug\u2010loading procedure was performed via supercritical CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010assisted impregnation technique. Silver nanoparticles were prepared via metal vapor synthesis and introduced into the composite biopolymer matrix. An analysis of the small\u2010angle X\u2010ray scattering profiles revealed that silver nanoparticles are characterized by having a logarithmic normal size distribution with the maximum at 25\u2009nm. The average size of particles determined from the broadening of diffraction peaks is in a good agreement with this result. The surface of the materials was characterized by X\u2010ray photoelectron spectroscopy. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    release kinetics of ibuprofen in phosphate buffer solution with pH = 7.4 from prepared materials was studied. The drug release to solution is governed by Fickian diffusion and can be described within the Ritger\u2013Peppas model. Introduction of silver nanoparticles has no effect on the diffusion mechanism. The as\u2010prepared materials are promising for the medical applications such as dressings for treatments of infected wounds and infection preventing. These materials can act as a matrix for transdermal drug administration. POLYM. ENG. SCI., 59:2479\u20132487, 2019. \u00a9 2019 Society of Plastics Engineers\n                  <\/jats:p>","DOI":"10.1002\/pen.25122","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:38:49Z","timestamp":1557409129000},"page":"2479-2487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Preparation and characterization of biomedical collagen\u2013chitosan scaffolds with entrapped ibuprofen and silver nanoparticles"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-6470","authenticated-orcid":false,"given":"Margarita S.","family":"Rubina","sequence":"first","affiliation":[{"name":"A.N. Nesmeyanov Institute of Organoelement Compounds, RAS  119991 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest E.","family":"Said\u2010Galiev","sequence":"additional","affiliation":[{"name":"A.N. 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