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Type 2 immune responses are essential for the repair of the lungs, hence Nb infection is a well\u2010established model to study immune\u2010mediated lung repair. We found that Nb infection was associated with increased HA in the lung, which peaked at d7 post\u2010infection (p.i.). Deposition of HA in the alveolar epithelium correlated with regions of damaged tissue and the type 2 immune response, which is characterized by eosinophilia and increased type 2 cytokines such as IL\u201013. Consistent with the accumulation of HA, we observed increased expression of the major synthase <jats:italic>Has2<\/jats:italic>, alongside decreased expression of <jats:italic>Hyal1, Hyal2<\/jats:italic>, and <jats:italic>Tmem2<\/jats:italic>, which can degrade existing HA. Expression of Tsg6 was also increased and correlated with the presence of inter\u2010\u03b1\u2010inhibitor heavy chain\u2013HA complexes (HC\u00b7HA) at d7 p.i. Using IL\u201013\u2010deficient mice, we found that the accumulation of HA during Nb infection was IL\u201013 dependent. Our data thus provide further evidence that IL\u201013 is a modulator of the HA matrix during lung challenge and links IL\u201013\u2010mediated HA regulation to tissue repair pathways.<\/jats:p>","DOI":"10.1002\/pgr2.70012","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:35:00Z","timestamp":1732602900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Injury From Nematode Lung Migration Induces an IL\u201013\u2010Dependent Hyaluronan Matrix"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-138X","authenticated-orcid":false,"given":"Rebecca J.","family":"Dodd","sequence":"first","affiliation":[{"name":"Wellcome Centre for Cell Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"},{"name":"Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences University of Manchester Manchester UK"},{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0869-1495","authenticated-orcid":false,"given":"Dora","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8409-5613","authenticated-orcid":false,"given":"Monika","family":"Vachiteva","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-5121","authenticated-orcid":false,"given":"James E.","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Cell Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"},{"name":"Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences University of Manchester Manchester UK"},{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-4621","authenticated-orcid":false,"given":"Brian H. 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