{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:01:11Z","timestamp":1789945271655,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2013,2]]},"abstract":"\n Study Objectives<\/jats:title>\n \n To develop and validate a self\u2010assessment adherence tool for imatinib in patients with chronic myeloid leukemia (\n CML<\/jats:styled-content>\n ), and to correlate the use of this tool with response to treatment and adverse effects.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Regional\n c<\/jats:styled-content>\n ancer center in\n F<\/jats:styled-content>\n rance.\n <\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n \n Forty\u2010six patients with chronic phase\n CML<\/jats:styled-content>\n treated with imatinib for 6\u00a0months or longer as of July 1, 2009.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements and main results<\/jats:title>\n We developed a self\u2010assessment questionnaire consisting of 10 questions to identify patients who were nonadherent to their cancer treatment. Each answer was worth 1 point, resulting in a possible maximum score of 10. The questionnaire was validated in patients receiving imatinib, using an objective adherence evaluation: a patient's score on the self\u2010assessment questionnaire was correlated with prescription refills, expressed as a medication possession ratio. A score of less than 8 was associated with a positive predictive value of 0.83 to have a medication possession ratio below 90%. With use of this questionnaire, half of the patients receiving imatinib would be identified as being nonadherent (sensitivity 0.5). Few adherent patients would be falsely identified as nonadherent, as the questionnaire's specificity was 0.97.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This self\u2010assessment questionnaire was validated for the first time in patients receiving imatinib for\n CML<\/jats:styled-content>\n treatment. It provides a simple practical tool for health care professionals to assess patient adherence during their routine clinical practice and to propose targeted interventions for those identified as possibly nonadherent.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/phar.1174","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T08:55:42Z","timestamp":1359363342000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Preliminary Validation of Self\u2010assessment Tool to Measure Imatinib Adherence in Patients with Chronic Myeloid Leukemia"],"prefix":"10.1002","volume":"33","author":[{"given":"Mikael","family":"Daouphars","sequence":"first","affiliation":[{"name":"Department of Pharmacy Cancer Centre Henri Becquerel Rouen 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