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Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug\u2010induced eosinophilic pneumonia.<\/jats:p>","DOI":"10.1002\/phar.1286","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T09:33:42Z","timestamp":1367573622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ceftaroline\u2010Induced Eosinophilic Pneumonia"],"prefix":"10.1002","volume":"33","author":[{"given":"Kunal R.","family":"Desai","sequence":"first","affiliation":[{"name":"Wright State University Boonshoft School of Medicine Miami Valley Hospital Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Wright State University Boonshoft School of Medicine Miami Valley Hospital Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari M.","family":"Polenakovik","sequence":"additional","affiliation":[{"name":"Wright State University Boonshoft School of Medicine Miami Valley Hospital Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Hagaman","sequence":"additional","affiliation":[{"name":"Wright State University Boonshoft School of Medicine Miami Valley Hospital Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M.","family":"Pleiman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Miami Valley Hospital Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis559"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0449-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr099"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq256"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939522"},{"key":"e_1_2_5_8_1","first-page":"1353","article-title":"Pulmonary infiltration with eosinophilia possibly induced by cefotiam in a case of steroid\u2010dependent asthma","volume":"28","author":"Irie M","year":"1990","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6574.776-d"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.86.1.138"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(03)00141-2"},{"key":"e_1_2_5_12_1","unstructured":"GeY HubbelA.In vitro evaluation of plasma protein binding and metabolic stability of ceftaroline (poster A\u20101935). 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